UTS2

  • Official Full Name

    urotensin 2

  • Overview

    This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.

  • Synonyms

    UTS2;UTS2 urotensin 2 [ Homo sapiens ];UII;U-II;UCN2;PRO1068;urotensin-2;urotensin 2;Urotensin II;OTTHUMP00000001356

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UTS2-506H Recombinant Human UTS2 Protein, His-tagged E.coli Human His Ser20~Trp120
UTS2-5137R Recombinant Rhesus monkey UTS2 Protein, His-tagged Mammalian Cells Rhesus macaque His
UTS2-51H Recombinant Human UTS2 protein, His-tagged E.coli Human His
UTS2-6483R Recombinant Rat UTS2 Protein Mammalian Cells Rat His
UTS2-7113C Recombinant Chicken UTS2 Mammalian Cells Chicken His
UTS2-4950R Recombinant Rhesus Macaque UTS2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
UTS2-4950R-B Recombinant Rhesus Macaque UTS2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
UTS2-5572H Recombinant Human UTS2 Protein (Pro36-Val124), N-His tagged E.coli Human His Pro36-Val124
UTS2-6139R Recombinant Rat UTS2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
UTS2-6139R-B Recombinant Rat UTS2 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    UTS2 involved in several pathways and played different roles in them. We selected most pathways UTS2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with UTS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction CIT,QRFP,GMIP,OMG,SPOP,OPN1LW1,ROR2,PCSK5,CNGA1,GPR18
    GPCR ligand binding CHRM5,ADM2,OPN1SW,OPN4A,TAS2R13,PRLH,ADCYAP1B,EMR1,KEL,RXFP2
    Peptide ligand-binding receptors GPR37L1,APLN,CCL27,UTS2D,PNOC,PMCH,SSTR1,NPS,PPY,SSTR4
    GPCR downstream signaling ABHD6B,RGS18,AMCF-II,RAMP1,MGLL,HRH3,GCGA,PROK1,PTH,GPR18
    Class A/1 (Rhodopsin-like receptors) UTS2D,RLN3A,OPN4B,RLN2,AGTR2,SSTR3,GPR65,SST1.1,OPN1MW2,CCR3
    G alpha (q) signalling events FFAR3,APPB,NMS,KISS1,CCK,EDN1,NMBA,AGTR1,ANXA1A,RGS19
    Signaling by GPCR CRHB,GPRC6A,TAC3,ARHGEF1B,GPR31B,GNA13B,HCAR1-2,RGS20,FGD2,XK
    Gastrin-CREB signalling pathway via PKC and MAPK CCK,TRH,CASR,DGKB,GPRC6A,NPS,ANXA1,TAC1,ANXA1C,QRFPR

    Protein Function

    UTS2 has several biochemical functions, for example, hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UTS2 itself. We selected most functions UTS2 had, and list some proteins which have the same functions with UTS2. You can find most of the proteins on our site.

    Function Related Protein
    hormone activity UCN2,RLN3,UTS2D,GPHB5,NPPC,UTS1,CRHR2,INSL3,AGT,FNDC5B
    receptor binding AKAP9,ECH1,PECR,MYO1C,HLA-G,CADM2,FGF24,FASLG,FYNA,INHA

    Interacting Protein

    UTS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UTS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UTS2.

    Resources

    Research Area

    Neurotransmitter Associated Enzymes

    References

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