VDAC2
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Official Full Name
voltage-dependent anion channel 2
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Overview
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. -
Synonyms
VDAC2; voltage-dependent anion channel 2; voltage-dependent anion-selective channel protein 2; outer mitochondrial membrane protein porin 2; POR; FLJ23841;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- VDAC2 Related Articles
VDAC2 involved in several pathways and played different roles in them. We selected most pathways VDAC2 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CHRNA7;TACR3A;PLCG1;ERBB3B;CALM1A;ADORA2AB;TNNC2;GRIN2D;GNA11A |
| cGMP-PKG signaling pathway | AGTR1A;MAPK3;PIK3R3;KCNMB3;ATP1B3;SRF;PDE2A;ATP2A1;PIK3R5 |
| Parkinsons disease | CASP9;NDUFA1;NDUFA9;NDUFB10;SLC25A4;NDUFV1;GNAI1;SEPT5;GNAI2 |
| Huntingtons disease | POLR2B;NDUFA13;PPIF;SIN3A;IFT57;Casp3;TBPL1;DNALC4;NDUFA8 |
| HTLV-I infection | WNT8A;Fzd4;GSK3B;WNT2B;CD3D;RELA;PDGFRB;POLD1;PRKACA |
VDAC2 has several biochemical functions, for example, nucleotide binding, porin activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC2 itself. We selected most functions VDAC2 had, and list some proteins which have the same functions with VDAC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | SRSF12;CLPXA;TUBA8L;ATAD1B;DHX57;DDX19;CPEB1B;MARF1;RBPMS2 |
| porin activity | TOMM40;VDAC2;TOMM40L;VDAC1;AQP9;VDAC3 |
| protein binding | BFSP1;PACSIN2;RPL23A;SELS;DDX41;DCAF7;ERC1;CHMP4B;CCDC6 |
| voltage-gated anion channel activity | GPR89;VDAC3;VDAC2;VDAC1;SLC17A3 |
VDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC2.
FAM162A; env; env; ACTB; DHRS2; CLN3; SERINC3; BAK1; TRAF6; q81y32_bacan; atoE; Trappc11; 15-deoxy-delta(12,14; MTX2; Mtx2; MME; ATF2
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