VPS4B

  • Official Full Name

    vacuolar protein sorting 4 homolog B (S. cerevisiae)

  • Overview

    The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
  • Synonyms

    VPS4B; vacuolar protein sorting 4 homolog B (S. cerevisiae); MIG1; SKD1; SKD1B; VPS4-2; vacuolar protein sorting-associated protein 4B; cell migration-inducing 1; vacuolar protein sorting 4B; suppressor of K+ transport defect 1; cell migration-inducing gene 1 protein; suppressor of K(+) transport growth defect 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VPS4B-3683H Recombinant Human VPS4B, His-tagged E.coli His 1-444aa
Human VPS4B-269H Recombinant Human vacuolar protein sorting 4 homolog B (S. cerevisiae), His-tagged E.coli His
Human VPS4B-383HCL Recombinant Human VPS4B 293 Cell Lysate HEK293 N/A
Human VPS4B-5193H Recombinant Human VPS4B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse VPS4B-18381M Recombinant Mouse VPS4B Protein Mammalian Cell His
Mouse VPS4B-10073M-B Recombinant Mouse VPS4B Protein Pre-coupled Magnetic Beads HEK293
Mouse Vps4b-6944M Recombinant Mouse Vps4b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse VPS4B-10073M Recombinant Mouse VPS4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque VPS4B-5173R Recombinant Rhesus monkey VPS4B Protein, His-tagged Mammalian Cell His
Rhesus Macaque VPS4B-4986R Recombinant Rhesus Macaque VPS4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque VPS4B-4986R-B Recombinant Rhesus Macaque VPS4B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish VPS4B-5909Z Recombinant Zebrafish VPS4B Mammalian Cell His
Zebrafish VPS4B-8439Z Recombinant Zebrafish VPS4B Mammalian Cell His
Chicken VPS4B-1521C Recombinant Chicken VPS4B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

VPS4B involved in several pathways and played different roles in them. We selected most pathways VPS4B participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisGRK7A;STAMBPB;HSPA1A;EPN1;ARF3B;SH3GL1B;FMNL3;ARPC2;HSPA2

VPS4B has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS4B itself. We selected most functions VPS4B had, and list some proteins which have the same functions with VPS4B. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTOP2B;SPS2;ATP13A5;EPHB2;P2RX6;DYRK4;MAP3K8;BBS10;PRKCDA
ATPase activityMYO9B;PSMD6;WRNIP1;ABCC12;KIF2C;KIF23;RNF213;ABCC1;KIF3CB
ATPase activity, coupledHSPA1B;MYO1E;HSPA8;VPS4B;MYH3;NSF;PEX1;HSPA6;ABCB1A
identical protein bindingCEP57L1;UBE4A;KHDRBS1;RAD52;GRB2;CLDN11;DYNLT1B;MNS1;CNTN2
NOT microtubule-severing ATPase activityVPS4A;VPS4B
protein C-terminus bindingHAND2;MSH2;PIAS3;PPP2CB;MKI67;KSR1;PRDX3;PPM1A;PEX12
protein bindingRAD1;Fgf15;GPI1;PLK2;VPS11;MUTYH;ORC2L;OSBPL6;KIFC3
protein homodimerization activityNUDT21;APOBEC3G;XDH;NR4A3;MAP3K10;IKZF2;EEA1;CHKA;DMBX1

VPS4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS4B here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS4B.

ZFYVE19; ZFYVE19; CHMP5; BABAM1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; RALA; EPHA2; Chmp4b

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