VPS4B
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Official Full Name
vacuolar protein sorting 4 homolog B (S. cerevisiae)
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Background
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008] -
Synonyms
VPS4B; vacuolar protein sorting 4 homolog B (S. cerevisiae); MIG1; SKD1; SKD1B; VPS4-2; vacuolar protein sorting-associated protein 4B; cell migration-inducing 1; vacuolar protein sorting 4B; suppressor of K+ transport defect 1; cell migration-inducing gene 1 protein; suppressor of K(+) transport growth defect 1;
- Involved Pathway
- Protein Function
- Interacting Protein
VPS4B involved in several pathways and played different roles in them. We selected most pathways VPS4B participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | RABEP1;WIPF2;TGFB1A;AGAP1;RAB11B;SPG20A;CYTH4B;WAS;GBF1 |
VPS4B has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS4B itself. We selected most functions VPS4B had, and list some proteins which have the same functions with VPS4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ADCY3;HSPA12B;CMPK;EPHB2B;YRK;HSPA4B;NLRP4B;MMAB;ACVR1BA |
| ATPase activity | SWSAP1;ASNA1;VCP;ATAD1B;DDX3X;MYO19;HSP90AA1;BLM;ATP13A3 |
| ATPase activity, coupled | CCT8;MYO1E;VPS4B;HSPA1A;HSPA6;MYH3;HSPA8;PEX1;HSPA1B |
| identical protein binding | LEPR;DAPK1;EED;DCTPP1;COL7A1;STAC3;MYOM1;ERBB2;LCP1 |
| NOT microtubule-severing ATPase activity | VPS4B;VPS4A |
| protein C-terminus binding | PABPC1;BLOC1S2A;CTGF;LIG4;MAPRE1;ARL6IP5;PXK;TAE1;YAP1 |
| protein binding | STX1A;PPP1R15B;HSPA6;SNRPD2;FST;PARK2;NDUFAF3;SMCR7;HOXA5 |
| protein homodimerization activity | FLT3LG;AMICA1;GSTM7;VWF;NUDT16;Anks6;Pdgfa&Pdgfb;SMAD4;NCR3 |
VPS4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS4B here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS4B.
ZFYVE19; ZFYVE19; CHMP5; BABAM1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; RALA; EPHA2; Chmp4b
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