WNT1

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WNT1

Official Full Name wingless-type MMTV integration site family, member 1
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Synonyms WNT1; wingless-type MMTV integration site family, member 1; INT1; OI15; BMND16; proto-oncogene Wnt-1; proto-oncogene Int-1 homolog; wingless-type MMTV integration site family, member 1 (oncogene INT1)
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • CHO Cell
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WNT1-110H Recombinant Human WNT1 Protein E. coli
    Human WNT1-204H Recombinant Human WNT1, StrepII-tagged Human Cell Strep II
    Human WNT1-304HCL Recombinant Human WNT1 293 Cell Lysate HEK293 N/A
    Human WNT1-560H Recombinant Human WNT1 E.coli N/A
    Mouse Wnt1-001M Recombinant Mouse Wnt-1/sFRP-1 Complex Protein CHO Cell N/A
    Mouse WNT1-18563M Recombinant Mouse WNT1 Protein Mammalian Cell His
    Zebrafish WNT1-7923Z Recombinant Zebrafish WNT1 Mammalian Cell His

    WNT1 involved in several pathways and played different roles in them. We selected most pathways WNT1 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway RAC2; MAP3K7; WNT7A; PRKCB; PPP3CA; FZD7; PRKACB; PRICKLE2B; FZD9; PRKACAB
    Hedgehog signaling pathway CSNK1G3; RAB23; DYRK1AA; GAS1B; STK36; PRKACB; LRP2A; GLI3; CSNK1G2A; PRKACA
    Hippo signaling pathway TCF7; GDF6; DLG3; JUB; CRB2; BMP4; GSK3B; PPP2R2A; TEAD4; CCND1
    Signaling pathways regulating pluripotency of stem cells AXIN2; MAPK3; WNT10B; MAP2K1; MAPK11; SMAD9; WNT16; LEFTY2; ID1; WNT1
    Melanogenesis PLCB1; FZD9; MAP2K1; PRKACAA; CAMK2B; WNT2B; CALML5; CREB3L3; WNT7A; PLCB4
    HTLV-I infection HLA-DPA1; PPP3R1; MYBL2; BCL2L1; PIK3R5; VCAM1; MSX2; NFKBIA; TGFBR1; HLA-DQA1
    Pathways in cancer NCOA4; GNB1; NRAS; FGF21; PDGFRA; IL-8; RUNX1T1; FGF7; FLT3LG; CTBP2
    Proteoglycans in cancer Fasl; WNT8B; CBL; MAPK1; PIK3CB; TIMP3; RDX; PPP1R12B; THBS1; HGF
    Basal cell carcinoma WNT3; GLI3; GSK3B; WNT7B; TCF7; FZD6; DVL2; WNT5A; AXIN1; PTCH1

    WNT1 has several biochemical functions, for example, cytokine activity, frizzled binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT1 itself. We selected most functions WNT1 had, and list some proteins which have the same functions with WNT1. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity KITLG; TGFB1A; BMP8A; IL29; Gm13290; IFNA4; MSTNA; TNFSF13; Cxcl15; FAM3D
    frizzled binding WNT7B; WNT7A; WNT5A; LRP6; SDCBP; RSPO3; WNT10B; WNT8A; WNT8B; WNT5B
    protein domain specific binding RUNX2; PLXND1; SNCA; CALM1; HIST1H4A; FOXA1; STX1B; MRPL17; IL1B; CSNK2B
    receptor agonist activity GAS6; WNT5A; WNT3A; CXCL13; GREM1; WNT7A; WNT8A; WNT3; VEGFA; WNT10B
    transcription regulatory region DNA binding ARID4A; DDIT3; SALL4; NR1D1; KLF1; TP73; ZFP821; HIVEP2; PROX1; BCL11AB

    WNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT1.

    Jing, D; Cai, J; et al. Pulsed Electromagnetic Fields Partially Preserve Bone Mass, Microarchitecture, and Strength by Promoting Bone Formation in Hindlimb-Suspended Rats. JOURNAL OF BONE AND MINERAL RESEARCH 29:2250-2261(2014).
    Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).

    WNT

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