ybx1

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ybx1

Official Full Name Y box binding protein 1
Background Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.<br/>The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
Synonyms YBX1; Y box binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse YBX1-1557M Recombinant Mouse YBX1 Protein (2-322 aa), His-tagged Yeast His
    Human YBX1-4852H Recombinant Human YBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ybx1-7029M Recombinant Mouse Ybx1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human YBX1-1945HCL Recombinant Human YBX1 cell lysate N/A
    Human YBX1-30136TH Recombinant Human YBX1, His-tagged E.coli His
    Human YBX1-3763H Recombinant Human YBX1, GST-tagged E.coli GST
    Human YBX1-4838H Recombinant Human YBX1, GST-tagged Wheat Germ GST
    Human YBX1-4839H Recombinant Human YBX1, GST-tagged Wheat Germ GST
    Human YBX1-636H Recombinant Human Y box binding protein 1, His-tagged E.coli His
    Human YBX1-6926H Recombinant Human YBX1, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse YBX1-18652M Recombinant Mouse YBX1 Protein Mammalian Cell His
    Rat YBX1-6625R Recombinant Rat YBX1 Protein Mammalian Cell His
    Chicken YBX1-5984C Recombinant Chicken YBX1 Mammalian Cell His
    Zebrafish YBX1-6756Z Recombinant Zebrafish YBX1 Mammalian Cell His

    ybx1 involved in several pathways and played different roles in them. We selected most pathways ybx1 participated on our site, such as BDNF signaling pathway, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with ybx1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway CNR1; SYN1; FRS2; DOK5; FRS3; CFL1; GRIP1; LINGO1; EEF2; SIRPA
    Gene Expression ZNF493; POLR3C; POU2F1B; KRBA1; EEF1A2; SKILB; NR2E3; ZNF738; ZNF92; SAP30L
    Processing of Capped Intron-Containing Pre-mRNA SNRNP25; HNRNPD; PCBP2; HNRNPH1L; HNRNPUL1; CLP1; NXF1; SNRNP48; PTBP1B; TTC6
    SIDS Susceptibility Pathways KCNJ8; PHOX2B; ECE1; KCNH2; SCN3B; SST; SP3; MAZ; YBX1; CDCA7L
    Signaling events mediated by PTP1B NOX4; YBX1; DOK1; CSN2
    mRNA Splicing DNAJC8; HNRNPH1; HNRNPH2; HNRNPD; SFRS3A; ZCRB1; YBX1; PTBP1A; HNRNPL; HNRNPH1L
    mRNA Splicing - Major Pathway SF3A3; HNRNPL2; CD2BP2; HNRNPH1L; SF3A1; HNRNPUL1; DNAJC8; CCAR1; HNRNPA0B; HNRNPL
    mRNA Splicing - Minor Pathway PRPF8; SNRNP25; PDCD7; SNRNP48; SF3B2; ZMAT5; RNPC3; ZCRB1; YBX1; SF3B4

    ybx1 has several biochemical functions, for example, DNA binding, GTPase binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ybx1 itself. We selected most functions ybx1 had, and list some proteins which have the same functions with ybx1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TOP2A; HOXB3A; RAD51L1; ADNP; ARID5B; FOXJ1; HIST1H2BG; HOXB5B; PMS1; RFX5
    GTPase binding VPS41; GOLGA4; RASA1; GM5506; PTPRN; HSP90AA1; GNB3; RAB3D; EPRS; IARS
    RNA binding SNRNP70; SRBD1; PABPC1L; ZFML; TRDMT1; IMPDH2; KHDC1A; EIF4EA; NCL; RPLP2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ELF3; KCNA3; HINFP; MYB; EBF1; FOSL1A; SP1; ZNF486; NFATC2; MYBL2
    chromatin binding SNAI2; RBMX; PRDM13; RDBP; MECP2; LHX2; NR5A5; SMARCD1; NPM2; DNMT3A
    double-stranded DNA binding CTNNB1; MTERF; PNKP; IFI16; TRP53; HNRPDL; FEV; MTERF3; RAD51; AIM2
    poly(A) RNA binding MRPL39; RBMS1; RRP1; RPL10; RPL15; TBCA; LRPPRC; ARHGEF1; RPL24; S100A4
    protein binding ETV4; IRF5; GMCL1; C11orf57; SMN1; BICC1; PPIC; PRPF40A; BRD3; Cd79a, Cd79b
    single-stranded DNA binding OBFC1; XRCC2; RAD51D; RPA4; NEIL3; SUB1; CNBP; XRCC3; CDC45; TEN1
    transcription factor activity, sequence-specific DNA binding HIF1AB; HOXA2B; UBN2B; RFXANK; TFAP2C; ZNF624; GATAD2A; RFX2; FOXE1; HIF1A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HIF1A; POU4F1; PATZ1; CEBPG; KLF4; POU2F3; RBPJ; NFATC2; BATF; NFIA

    ybx1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ybx1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ybx1.

    SYNCRIP; C1QBP; HNRNPR; DHX9

    Blackwell, E; Ceman, S; et al. A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein. JOURNAL OF CELL SCIENCE 124:3060-3065(2011).

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