ywhae
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  • Official Full Name
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Background
  • 14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms
  • YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; 14-3-3 protein epsilon; 14 3 3 epsilon; FLJ45465; 14-3-3 epsilon; protein kinase C inhibitor protein-1; mitochondrial import stimulation factor L subunit
Cat.#:YWHAE-150HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-1193MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse YWHAE, GST-tagged
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Cat.#:YWHAE-019HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-137HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-26003THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-26004THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-26006THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-873HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE, None tagged
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Cat.#:YWHAE-878HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE, GST tagged
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Cat.#:Ywhab-138MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ywhae Protein, His-tagged
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Cat.#:YWHAE-18683MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YWHAE Protein
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Cat.#:YWHAE-888MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse YWHAE Protein, GST-tagged
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Cat.#:YWHAE-6638RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YWHAE Protein
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Cat.#:YWHAE-1093CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus YWHAE Protein, His-tagged
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Cat.#:YWHAE-1367CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YWHAE
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Cat.#:YWHAE-740HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human YWHAE lysate
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Involved Pathway

YWHAE involved in several pathways and played different roles in them. We selected most pathways YWHAE participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
NIPBLB; STAG2A; CSNK1D; CSNK1E; ORC3L; NDE1; SMAD3; SPC25; RAD17; ACTR1A
Oocyte meiosis
PPP2R5CB; PPP3R1B; MAPK12B; CALM2A; PPP1CBL; SMC1AL; RPS6KA3B; CPEB1; CCNB2; CCNE2
PIK-Akt signaling pathway
IGF1R; PRKAA2; NFKB1; FOXO3; Il6ra; FGF2; FGFR2; IFNA16; FN1; IL3RA
Hippo signaling pathway
FZD8; FBXW11; ID2; PPP2R1B; PPP2R2C; DVL3; BMP8A; TGFB1; WNT7A; WNT8B
Neurotrophin signaling pathway
SHC2; PIK3CG; SORT1; RAC1; IRAK1; MAPK3; FOXO3; PSEN1; RPS6KA1; PLCG2
Epstein-Barr virus infection
BCL2; POLR2K; HLA-DRB5; PSMC3; POLR3E; HLA-C; PSMC1; POLR2G; RIPK1; TBPL2
Viral carcinogenesis
YWHAE; PIK3R1; PRKACG; MAPKAPK2; CASP8; BAK1; HIST2H4; PXN; HIST2H4A; ATP6V0D2

Protein Function

YWHAE has several biochemical functions, for example, MHC class II protein complex binding, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAE itself. We selected most functions YWHAE had, and list some proteins which have the same functions with YWHAE. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein complex binding
Related Protein CD81; ANXA11; HLA-DOA; HLA-DRB1; HLA-DMB; PKM; YWHAE; CD74; HSP90AA1; ATP1B1
Function enzyme binding
Related Protein CBX4; PCCA; BTG1; TSPAN17; KDM4C; HIST1H2AG; RARA; BLZF1; LDB1; P4HB
Function histone deacetylase binding
Related Protein SUDS3; GLI3; SP2; HDAC3; NKX3-1; KAT2A; HOXA10; GCM1; GMNN; TOP2A
Function ion channel binding
Related Protein VDAC1; DIAPH1; KCNIP1; CALM1; YES1; CHERP; YWHAH; CAV3; KCND3; LYN
Function phosphoprotein binding
Related Protein GPRIN1; FKBP4; SAG; DPYS; LYN; LRP11; PIH1D1; MID2; PLAT; PITX2
Function phosphoserine binding
Related Protein YWHAE; NEDD4; YWHAB; PIN1
Function poly(A) RNA binding
Related Protein HUWE1; GTPBP10; EXOSC10; HIST1H1D; POLRMT; PSMC1; MTIF2; FIP1L1; TWF2; BRIX1
Function potassium channel regulator activity
Related Protein AKAP9; LRRC26; ARPP19; ARPP19A; KCNIP2; KCNS3; YWHAE; SGK2; PRKCZ; DRD4
Function protein binding
Related Protein PLEKHG6; FARSA; C12orf68; TDG; RAB1; MPZL3; CDKN1A; LY96; PPP1R11; INCA1
Function protein domain specific binding
Related Protein SHROOM2; RAB27A; LIN7C; RAB6A; WHRN; CBX3; TNFAIP1; WNT1; TNNI3; CALM
Function protein heterodimerization activity
Related Protein SMC1A; ARNT; SFRP5; HIST1H2BN; SPTAN1; PDSS1; HIST1H47; NEFH; HSPD1; PPP2R1A
Function ubiquitin protein ligase binding
Related Protein ARRB1; DIO2; SPG20; TSG101; WASH; RPA2; UBE2J2; PER1; MID1; SMAD3

Interacting Protein

YWHAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAE here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAE.
YWHAZ; LRRK2; HDAC4; ATXN1