Adipolysis Assay Kit

Cat.No. : Kit-0054
Product Overview : Adipolysis Assay Kit is a quantitative colorimetric/fluorimetric assay for adipolysis.
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Applications : Direct Assays: adipolysis (glycerol in cell culture media).Drug Discovery/Pharmacology: effects of testing drugs on adipolysis.
Storage : The kit is shipped on ice. Store Assay Buffer at 4°C and other reagents at -20°C.Shelf life of 3 months after receipt.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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Can stress affect adipolysis protein activity? 02/21/2022

Yes, stress can affect adipolysis protein activity by altering the release of certain hormones, such as cortisol and adrenaline, which can stimulate lipolysis. Chronic stress has been linked to increased adipose tissue inflammation and insulin resistance, which may be related to dysregulated adipolysis. Therefore, stress management techniques may be beneficial for individuals with metabolic disorders.

What future research is being conducted regarding adipolysis proteins and metabolic disorders? 12/01/2021

Researchers are continuing to explore the molecular mechanisms that underlie adipolysis and its role in metabolic regulation. They are also studying the safety and efficacy of new drugs that target adipolysis proteins, as well as ways to effectively combine these drugs with other therapies for obesity and metabolic disorders. Additionally, there is growing interest in biomarkers and diagnostic tools that can more accurately predict an individual's risk for these conditions and guide personalized treatment decisions.

How can Adipolysis proteins be targeted with medication? 02/13/2021

Several drugs that target Adipolysis proteins are currently in development for the treatment of metabolic disorders. For example, inhibitors of ATGL have shown promise in preclinical studies as potential therapies for obesity and type 2 diabetes. Similarly, activators of HSL, which promote fat breakdown, may also have therapeutic potential. Other drugs that target Adipolysis signaling pathways, such as AMPK activators and PPAR agonists, may also modulate Adipolysis protein expression and function.

What are some potential risks or side effects of modulating adipolysis proteins? 11/04/2020

The effects of modulating adipolysis proteins will depend on the specific protein targeted and the nature of the drug used. In general, drugs that enhance lipolysis may cause weight loss, but may also increase the risk of insulin resistance and other metabolic complications. Conversely, drugs that inhibit lipolysis may promote weight gain and metabolic dysfunction. It will be important for researchers to carefully study the long-term effects and risks of these drugs before they are widely used in clinical practice.

Are there any genetic mutations or variations that can affect Adipolysis proteins? 09/29/2020

Yes, genetic mutations or variations may affect Adipolysis proteins and contribute to the development of metabolic disorders. For example, mutations in the genes encoding HSL and ATGL may impair their function and lead to the accumulation of fat in adipocytes. Additionally, genetic variations in Adipolysis signaling pathways may affect the regulation of Adipolysis protein expression and activity. However, the impact of genetic variations on Adipolysis proteins and metabolic health is still an active area of research.

Can targeting adipolysis proteins be used to treat other diseases besides obesity and metabolic disorders? 09/17/2020

Yes, targeting adipolysis proteins may have potential therapeutic applications beyond obesity and metabolic disorders. For example, certain types of cancer cells rely on lipolysis as a source of energy, and inhibiting adipolysis enzymes may be a promising strategy for preventing cancer growth and progression. Additionally, adipolysis pathways may be involved in the pathogenesis of other disorders such as cardiovascular disease and neurodegenerative diseases, and further research is needed to explore these potential links.

Are there any drugs that target or modulate adipolysis proteins? 07/10/2020

Yes, there are several drugs in development that target adipolysis proteins as a means of treating obesity and metabolic disorders. For example, a drug called tesofensine inhibits the reuptake of neurotransmitters involved in appetite regulation, and also acts on HSL to increase lipolysis in adipose tissue.

How do adipolysis proteins affect insulin sensitivity? 07/08/2020

Adipolysis proteins play a key role in the mobilization and utilization of stored fat as an energy source. By enhancing lipolysis and increasing the release of fatty acids from adipose tissue, these proteins can improve insulin sensitivity and help prevent the development of insulin resistance. However, excessive or prolonged activation of adipolysis proteins may lead to the release of too many fatty acids, which can promote insulin resistance and metabolic dysfunction.

Can targeting adipolysis proteins also affect other organs besides adipose tissue? 02/16/2020

Yes, adipolysis proteins can affect other organs besides adipose tissue, such as the liver and pancreas. Excessive fatty acid uptake by these organs can lead to lipid accumulation, inflammation, and insulin resistance, contributing to the development of metabolic disorders. Therefore, drugs that target adipolysis proteins must be carefully designed to minimize off-target effects and maximize benefits.

What other therapies are currently available for obesity and metabolic disorders? 09/09/2019

In addition to adipolysis-targeting drugs, there are several other therapies available for obesity and metabolic disorders. These may include lifestyle interventions such as diet and exercise, pharmacological agents that affect appetite or metabolism, and surgical interventions such as gastric bypass surgery. The choice of therapy will depend on individual patient factors and the severity of their condition.

Are there any genetic factors that influence adipolysis protein activity? 09/03/2019

Yes, genetic variations in the genes that encode adipolysis proteins can affect their activity and expression. Some studies have identified genetic variants that are associated with obesity and metabolic disorders, and that may affect adipolysis pathways in adipose tissue. Further research is needed to fully understand the genetic and molecular mechanisms that underlie these associations.

Can lifestyle changes affect Adipolysis proteins? 06/22/2019

Yes, lifestyle changes can affect Adipolysis proteins. Regular exercise and a healthy diet have been shown to improve Adipolysis by increasing the expression and activation of key Adipolysis proteins such as HSL and ATGL. Conversely, a sedentary lifestyle and high-fat diet may dysregulate Adipolysis and contribute to the development of metabolic disorders. Additionally, some dietary supplements such as caffeine and green tea extract have been shown to enhance Adipolysis through the activation of Adipolysis proteins.

How do hormones such as leptin and insulin regulate adipolysis? 02/09/2018

Leptin and insulin are two hormones that play an important role in regulating adipolysis. Leptin, which is produced by adipocytes, inhibits lipolysis by activating signaling pathways that decrease the activity of adipolysis enzymes. By contrast, insulin stimulates lipolysis by increasing the activity of hormone-sensitive lipase and other adipolysis enzymes. These opposing effects of leptin and insulin help to maintain the balance between energy storage and utilization in the body.

Can lifestyle changes affect adipolysis protein levels? 12/15/2017

Yes, certain lifestyle factors such as diet and exercise can influence the expression and activity of adipolysis proteins. For example, consuming a high-fat or high-carbohydrate diet can increase the production of adipolysis enzymes and enhance lipolysis in adipose tissue. Similarly, exercise can stimulate the expression of certain adipolysis proteins and improve the efficiency of fat oxidation.

What are some examples of adipolysis proteins? 08/21/2017

Some examples of adipolysis proteins include hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and monoacylglycerol lipase (MAGL). Each of these enzymes plays a distinct role in the breakdown of triglycerides (fat molecules) in adipose tissue.

How do adipolysis proteins affect inflammation in adipose tissue? 06/07/2017

Adipolysis proteins can affect inflammation in adipose tissue through several mechanisms. Excessive lipolysis can release high levels of fatty acids into the circulation, which can activate inflammatory pathways and contribute to chronic low-grade inflammation. Additionally, adipolysis enzymes may directly promote inflammation by stimulating the expression of pro-inflammatory cytokines. Inflammation in adipose tissue is thought to be a key contributor to insulin resistance and metabolic dysfunction.

What are Adipolysis proteins and what do they do? 01/12/2016

Adipolysis proteins are a group of proteins that play a key role in regulating the breakdown of stored fat in adipocytes. These proteins include hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), perilipins, and several other proteins involved in lipid metabolism and signaling pathways. HSL and ATGL are responsible for the hydrolysis of triglycerides into free fatty acids and glycerol, while perilipins and other proteins regulate the access of HSL and ATGL to the triglycerides stored in lipid droplets.

Customer Reviews (4)

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Reviews
06/05/2021

    The manufacturer's excellent track record in producing high-quality proteins and providing dependable technical support has instilled confidence in my ability to obtain optimal results in my research.

    12/27/2020

      The protein was easy to use and worked well in my application, saving me time and effort in my research.

      12/24/2019

        The reasonable price coupled with the superior quality of the product has made it a highly cost-effective choice for my application.

        10/14/2016

          The protein showed good stability during the experiment

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