"EEF2K" Related Products

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Recombinant Human Eukaryotic Elongation Factor-2 Kinase, GST-tagged

Cat. No.: EEF2K-1879H
Product Overview: Recombinant humanfull length EEF2K GST-Tagged.
Description: EEF2K is a highlyconserved protein kinase in the calmodulin-mediated signaling pathwaythat links activation of cell surface receptors to cell division. This kinaseis involved in the regulation of protein synthesis. It phosphorylateseukaryotic elongation factor 2 and thus inhibits the EEF2 function. Theactivity of this kinase is increased in many cancers and may be a validtarget for anti-cancer treatment.
Source: E. coli
Species: Human
Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight: 109.8 kDa calculatedfrom the amino acid sequence below.
Amino Acid Sequence: MSPILGYWKIKGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHNMLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTHPDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSDLVPRPWSNQT SLYKKAGTMA DEDLIFRLEG VDGGQSPRAG HDGDSDGDSD DEEGYFICPI TDDPSSNQNVNSKVNKYYSN LTKSERYSSS GSPANSFHFK EAWKHAIQKA KHMPDPWAEF HLEDIATERA TRHRYNAVTGEWLDDEVLIK MASQPFGRGA MRECFRTKKL SNFLHAQQWK GASNYVAKRY IEPVDRDVYF EDVRLQMEAKLWGEEYNRHK PPKQVDIMQM CIIELKDRPG KPLFHLEHYI EGKYIKYNSN SGFVRDDNIR LTPQAFSHFTFERSGHQLIV VDIQGVGDLY TDPQIHTETG TDFGDGNLGV RGMALFFYSH ACNRICESMG LAPFDLSPRERDAVNQNTKL LQSAKTILRG TEEKCGSPRV RTLSGSRPPL LRPLSENSGD ENMSDVTFDS LPSSPSSATPHSQKLDHLHW PVFSDLDNMA SRDHDHLDNH RESENSGDSG YPSEKRGELD DPEPREHGHS YSNRKYESDEDSLGSSGRVC VEKWNLLNSS RLHLPRASAV ALEVQRLNAL DLEKKIGKSI LGKVHLAMVR YHEGGRFCEKGEEWDQESAV FHLEHAANLG ELEAIVGLGL MYSQLPHHIL ADVSLKETEE NKTKGFDYLL KAAEAGDRQSMILVARAFDS GQNLSPDRCQ DWLEALHWYN TALEMTDCDE GGEYDGMQDE PRYMMLAREA EMLFTGGYGLEKDPQRSGDL YTQAAEAAME AMKGRLANQY YQKAEEAWAQ MEE
Concentration: 0.43 mg/ml
Purity: ≥ 75% as determinedby SDS-PAGE analysis.
Specific Activity: 148 nmole ofphosphate transferred to EF2tide (RKKFGESEKTKTKEFL) per min per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 3.33μg/ml.
Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: EEF2K
Gene Name: EEF2K eukaryotic elongationfactor-2 kinase [ Homo sapiens ]
Synonyms: EEF2K; eukaryoticelongation factor-2 kinase; eEF-2K; HSU93850; MGC45041; eukaryoticelongation factor 2 kinase; eEF-2 kinase; OTTHUMP00000119998; elongationfactor-2 kinase; eukaroytic elongation factor 2 kinase; calmodulin-dependentprotein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor2 kinase
Gene ID: 29904
mRNA Refseq: NM_013302
Protein Refseq: NP_037434
MIM: 606968
UniProt ID: O00418
Chromosome Location: 16p12
Pathway: IRS-mediatedsignalling; IRS-related events; Insulin receptor signalling cascade; PI3KCascade; PKB-mediated events; S6K1 signalling; S6K1-mediated signalling;Signal Transduction; Signaling by Insulin receptor; Signaling mediated byp38-gamma and p38-delta; Translation Factors; mTOR signaling pathway; mTORsignalling; mTORC1-mediated signalling
Function: ATP binding; calciumion binding; calmodulin binding; elongation factor-2 kinase activity;nucleotide binding; protein kinase activity; protein serine/threonine kinaseactivity; translation factor activity, nucleic acid binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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