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Recombinant Human Misshapen-Like Kinase 1 (zebrafish), GST-tagged

Cat.No. : MINK1-5455H
Product Overview : Recombinant humanMINK1 catalytic domain (amino acids 1-320), GST-tagged. MINK1 is aserine/threonine kinase belonging to the germinal center kinase (GCK) family.No special measures were taken to activate this kinase.
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Cat. No. : MINK1-5455H
Description : MINK1 is a member of thegerminal center family of kinases that are homologous to the Ste20 family andregulate a wide variety of cellular processes, including cell morphology,cytoskeletal rearrangement, and survival. Overexpression of kinase-deadmutants of MINK1 leads to enhanced cell spreading, actin stress fiberformation, adhesion to extracellular matrix and decreased cell motility andinvasion. MINK is activated after Ras induction via a mechanism involvingreactive oxygen species and mediates stimulation of p38 MAPK downstream ofthe Raf/ERK pathway.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Purity : ≥ 90% asdetermined by SDS-PAGE analysis
Molecular Weight : 63.9 kDa
Specific Activity : 250 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33 μg/ml.
storage : Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : MINK1
Pathways : Insulin Signaling; MAPK signaling pathway
Gene Name : MINK1 misshapen-like kinase 1 [Homo sapiens ]
Synonyms : MINK1; misshapen-like kinase 1(zebrafish); B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKbeta; GCKfamily kinase MINK; misshapen/NIK-related kinase; serine/threonine proteinkinase; EC 2.7.11.1; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6;MEKKK 6; Mitogen-activated protein kinase kinase kinase kinase 6;misshapen-like kinase 1 (zebrafish)
Gene ID : 50488
mRNA Refseq : NM_001024937
Protein Refseq : NP_001020108
MIM : 609426
UniProt ID : Q8N4C8
Chromosome Location : 17p13.2
Function : ATP binding; nucleotidebinding; protein binding; protein serine/threonine kinase activity; smallGTPase regulator activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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