Recombinant Human Misshapen-Like Kinase 1 (zebrafish), GST-tagged
Cat.No. : | MINK1-5455H |
Product Overview : | Recombinant humanMINK1 catalytic domain (amino acids 1-320), GST-tagged. MINK1 is aserine/threonine kinase belonging to the germinal center kinase (GCK) family.No special measures were taken to activate this kinase. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MINK1-5455H |
Description : | MINK1 is a member of thegerminal center family of kinases that are homologous to the Ste20 family andregulate a wide variety of cellular processes, including cell morphology,cytoskeletal rearrangement, and survival. Overexpression of kinase-deadmutants of MINK1 leads to enhanced cell spreading, actin stress fiberformation, adhesion to extracellular matrix and decreased cell motility andinvasion. MINK is activated after Ras induction via a mechanism involvingreactive oxygen species and mediates stimulation of p38 MAPK downstream ofthe Raf/ERK pathway. |
Source : | Insect cells |
Species : | Human |
Form : | Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol. |
Purity : | ≥ 90% asdetermined by SDS-PAGE analysis |
Molecular Weight : | 63.9 kDa |
Specific Activity : | 250 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33 μg/ml. |
storage : | Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles. |
OfficialSymbol : | MINK1 |
Pathways : | Insulin Signaling; MAPK signaling pathway |
Gene Name : | MINK1 misshapen-like kinase 1 [Homo sapiens ] |
Synonyms : | MINK1; misshapen-like kinase 1(zebrafish); B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKbeta; GCKfamily kinase MINK; misshapen/NIK-related kinase; serine/threonine proteinkinase; EC 2.7.11.1; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6;MEKKK 6; Mitogen-activated protein kinase kinase kinase kinase 6;misshapen-like kinase 1 (zebrafish) |
Gene ID : | 50488 |
mRNA Refseq : | NM_001024937 |
Protein Refseq : | NP_001020108 |
MIM : | 609426 |
UniProt ID : | Q8N4C8 |
Chromosome Location : | 17p13.2 |
Function : | ATP binding; nucleotidebinding; protein binding; protein serine/threonine kinase activity; smallGTPase regulator activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
MINK1-5342H | Active Recombinant Human MINK1 Protein, GST/His-tagged | +Inquiry |
MINK1-1353H | Recombinant Human MINK1 Protein, MYC/DDK-tagged | +Inquiry |
Mink1-4075M | Recombinant Mouse Mink1 Protein, Myc/DDK-tagged | +Inquiry |
MINK1-1078H | Recombinant Human MINK1 Protein (M1-G314), Tag Free | +Inquiry |
MINK1-1079H | Recombinant Human MINK1 Protein (M1-G314), GST tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket