Recombinant Mouse Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (granulocyte-macrophage), His-tagged

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Recombinant Mouse Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (granulocyte-macrophage), His-tagged

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Cat. No. : Csf2ra-5615M
Product Overview : Recombinant Mouse Csf2raprotein was expressed in Murine myeloma cell line with aC-terminal 6-His tag. Leu30-Pro327.
Description : Csf2ra, also knownas CD116, is a component of the receptor complex that mediates cellularresponses to GMCSF. GMCSF promotes the differentiation and mobilization ofgranulocyte-macrophage, erythroid, megakaryocyte, and eosinophil progenitors.It enhances the activation of myeloid cell effector functions and plays arole in the development of Th1 biased immune responses, allergicinflammation, and autoimmunity.
Source : Murine myeloma cellline, NS0-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Leu30
Molecular Weight : 32.8 kDa
Activity : Measuredby its ability to inhibit GM-CSF-dependent proliferation of DA3 mouse myelomacells. The ED50 for this effect is typically 0.5-3 μg/mL in thepresence of 0.1 ng/mL of rmGM-CSF.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 55-65kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 500 μg/mL in PBS
Storage : Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Csf2ra colony stimulatingfactor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Musmusculus ]
Official Symbol : Csf2ra
Synonyms : Csf2ra; colonystimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CD116;Csfgmra; GM-CSFR; GM-CSF-Ra; granulocyte-macrophage colony-stimulating factorreceptor subunit alpha; GMR-alpha; GM-CSFRalpha; GMCSFR-alpha;GM-CSF-R-alpha; colony stimulating factor 2 receptor alpha chain
Gene ID : 12982
mRNA Refseq : NM_009970
Protein Refseq : NP_034100
UniProt ID : Q00941
Chromosome Location : 19 D3; 19 51.0 cM
Pathway : Cytokine Signalingin Immune system; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; Immune System; Interleukin receptor SHC signaling; Interleukin-2signaling; Interleukin-3, 5 and GM-CSF signaling; Jak-STAT signaling pathway;Pathways in cancer; Signaling by Interleukins
Function : cytokine receptoractivity; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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