"ACRV1" Related Products

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Mouse Anti-Human Acrosomal Vesicle Protein 1 Monoclonal Antibody

Cat.No.: CAB11477MH
Product Overview: Mouse monoclonal antibody to human acrosomal vesicle protein 1.
Antigen Description: Acrosomal protein SP-10, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. The longest transcript of ACRV1 / SP-10 is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for< 1% of the total acrosomal vesicle protein 1 message. acrv1 sp-10 is a testis-specific acrosomal protein that has been detected in several species including humans. it may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. acrv1 sp-10 may be involved in sperm-zona binding or penetration. it is also a intra-acrosomal protein that is considered to be a vaccine candidate for>
Specificity: Human ACRV1. No cross-reactivity with human cell lysate ( 293 cell line ) in ELISA.
Immunogen: Recombinant Human ACRV1 Protein
Host: Mouse
Isotype: Mouse IgG1
Species: Human
Clone: 4E3G11
Purification: Protein A affinity chromatography
Applications: Western Blot; ELISA
Dilution: Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Human ACRV1 in WB. Using a DAB detection system, the detection limit for Human ACRV1 is approximately 20 ng/lane under non-reducing conditions and reducing conditions.Direct ELISA: This antibody can be used at 0.5 - 1 μg with the appropriate secondary reagents to detect Human ACRV1. The detection limit for Human ACRV1 is approximately 0.0195 ng/well.
Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human ACRV1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Format: 0.2 μm filtered solution in PBS with 5% trehalose
Storage: This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name: ACRV1 acrosomal vesicle protein 1 [ Homo sapiens ]
Official Symbol: ACRV1
Synonyms: ACRV1; acrosomal vesicle protein 1; acrosomal protein SP-10; D11S4365; SP 10; SPACA2; sperm protein 10; SP-10;
Gene ID: 56
mRNA Refseq: NM_001612
Protein Refseq: NP_001603
MIM: 102525
UniProt ID: P26436
Chromosome Location: 11p12-q13

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