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Recombinant Mouse Interferon Beta 1, Fibroblast, Fc-tagged

Cat.No. : Ifnb1-177M
Product Overview : A DNA sequence encoding the extracellular domain of mouse Ifnb1 was fused with the Fc region of human IgG1 at the C-terminus. The secreted recombinant mouse Ifnb1 is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and has a calculated molecular mass of 46.7 kDa.
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  • Gene Information
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Description : Ifnb1 is one type of IFN beta proteins that is a member of the Interferon type I family. Ifnb1 is produced in large quantities by fibroblasts and binds to a specific cell surface receptor complex known as the IFN alpha receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains as other members of IFN1 famlily do. The induction of interferon beta (Ifnb1) is a key event in the antiviral immune response. It has shown that treatment with IFN beta affects NK cell cycle without altering NK cell apoptosis in MS patients. Treated with IFN beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle. There was no difference in NK cell apoptosis markers. Synthetic interferons (IFNs) are used in the treatment of several types of cancer. It has also been proved that apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phase.
Source : Human Cells
Species : Mouse
Tag : Fc
Predicted N Terminal : Ile 22
Form : Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Molecular Mass : The secreted recombinant mouse Ifnb1 is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and has a calculated molecular mass of 46.7 kDa. As a result of glycosylation, the apparent molecular mass of rmIfnb1 monomer is approximately 58 kDa in SDS-PAGE under reducing conditions.
Protein length : 402 amino acids
Endotoxin : 1.0 eu/μg of the protein as determined by the lal
Purity : >92 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 °C.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Ifnb1 interferon beta 1, fibroblast [ Mus musculus ]
Official Symbol : Ifnb1
Synonyms : IFNB1; interferon beta 1, fibroblast; interferon beta; Ifb; IFNB; IFN-beta;
Gene ID : 15977
mRNA Refseq : NM_010510
Protein Refseq : NP_034640
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response (Bi°Carta), organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem;
Function : cytokine activity; cytokine receptor binding; transcription corepressor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any contraindications for IFNB1 treatment? 01/26/2021

IFNB1 is generally not recommended for individuals with a history of hypersensitivity to interferons or other components of the drug. It should be used with caution in patients with certain pre-existing medical conditions.

Can IFNB1 be used in cancer treatment? 02/11/2020

IFNB1 is being investigated for its potential role in cancer treatment due to its immunomodulatory effects. Clinical trials are ongoing to evaluate its efficacy in various types of cancer.

What are the potential side effects of IFNB1 treatment? 06/27/2019

Common side effects include flu-like symptoms, injection site reactions, and changes in blood cell counts. Serious side effects are rare but can include liver problems and allergic reactions.

How is IFNB1 administered in clinical settings? 06/04/2019

IFNB1 is often administered through subcutaneous or intramuscular injections. The frequency and dosage depend on the specific condition being treated.

In what other conditions is IFNB1 protein clinically utilized? 10/09/2016

IFNB1 is also used in the treatment of certain viral infections, such as hepatitis B and C. It has antiviral properties that can inhibit viral replication.

Customer Reviews (3)

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Reviews
06/24/2021

    The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

    08/29/2020

      the IFNB1 protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

      11/08/2018

        manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

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