Recombinant Human Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus)

• Cat.No.: COCH-3899H
• Product Overview: A DNA sequence encoding the mature form of human COCH (NP_001128530.1) (Glu 25-Gln 550) was expressed, with a polyhistidine tag at the N-terminus.

Specification

• Cat. No.: COCH-3899H
• Description: COCH, is a secreted protein which contains one LCCL domain and two VWFA domains. Cochlin / COCH is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin / COCH and type II collagen are major constituents of the inner ear extracellular matrix, and COCH constitutes 70% of non-collagenous protein in the inner ear and the expression is highly specific.
• Source: Human
• Host: Human Cells
• Form: Lyophilized from sterile PBS, pH 7.4.
• Purity: > 92 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: His
• Molecular Mass: The recombinant full length of human COCH consists of 542 amino acids and has a calculated molecular mass of 59.4 kDa. In SDS-PAGE under reducing conditions, rhCOCH migrates as three bands with apparent molecular mass of 66, 48 and 18 kDa, corresponding to the alternative splicing isoforms.
• Application: SDS-PAGE
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information
• Storage: Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: COCH coagulation factor C homolog, cochlin (Limulus polyphemus) [ Homo sapiens ]
• Official Symbol: COCH
• Synonyms: COCH; coagulation factor C homolog, cochlin (Limulus polyphemus); DFNA9; COCH5B2; COCH-5B2; cochlin; OTTHUMP00000178782
• Gene ID: 1690
• mRNA Refseq: NM_001135058
• Protein Refseq: NP_001128530
• MIM: 603196
• UniProt ID: O43405
• Chromosome Location: 14q11.2-q13