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Recombinant Human Activin A Receptor, Type I, His-tagged

Cat.No. : ACVR1-984H
Product Overview : Recombinant human ACVR1 (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Cat. No. : ACVR1-984H
Description : ACVR1 is a receptor serine/threonine kinase that is member of the ACVR family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ACVR1, but not TGFβRI (ACVR1), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1 pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.
Applications : Kinase Assay; Western Blot
Molecular Weight : 67 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 46 nmol/min/mg
Purity : > 90 %
Concentration : 0.1 ug/ul
Sequences : 147-end
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : ALK1 pathway; ALK1 signaling events; ALK2 signaling events; Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Gene Name : ACVR1 activin A receptor, type I [ Homo sapiens ]
Official Symbol : ACVR1
Synonyms : ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; Activin receptor type-1; EC 2.7.11.30; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; TSR-I; OTTHUMP00000162806; OTTHUMP00000204626; OTTHUMP00000240120
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
MIM : 102576
UniProt ID : Q04771
Chromosome Location : 2q23-q24
Function : ATP binding; SMAD binding; activin binding; contributes_to activin receptor activity, type I; follistatin binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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