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Recombinant Human Histone Deacetylase 10, GST-tagged

Cat.No. : HDAC10-1588H
Product Overview : Recombinant human HDAC10 (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Cat. No. : HDAC10-1588H
Description : HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors.
Applications : HDAC Assay, Western Blot
Molecular Weight : 77 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity : >80%
Concentration : 0.1 ug/ul
Specific Activity : 120 RLU/min/ng
Sequences : 1-482
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Signaling events mediated by HDAC Class I; NAD-dependent histone deacetylase activity (H3-K14 specific)
Gene Name : HDAC10 histone deacetylase 10 [ Homo sapiens ]
Official Symbol : HDAC10
Synonyms : HDAC10; histone deacetylase 10; HD10; MGC149722; DKFZp761B039; histone deacetylase 10; OTTHUMP00000042162; OTTHUMP00000196674; OTTHUMP00000196675; OTTHUMP00000197621
Gene ID : 83933
mRNA Refseq : NM_032019
Protein Refseq : NP_114408
MIM : 608544
UniProt ID : Q969S8
Chromosome Location : 22q13
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; protein deacetylase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does HDAC10 impact neuronal function? 01/01/2023

HDAC10 may influence neuronal function by regulating the acetylation status of proteins involved in synaptic plasticity and neurodevelopment.

How does HDAC10 influence immune response in cancer? 09/03/2020

HDAC10 may affect the immune response by modulating the expression of genes involved in immune regulation, making it a potential target for immunotherapy.

What are the specific clinical applications of HDAC10 in cancer treatment? 02/22/2019

HDAC10 inhibitors are being explored as potential anti-cancer agents, as they could help regulate gene expression and inhibit the growth of cancer cells.

Are there any ongoing clinical trials targeting HDAC10 in cancer therapy? 10/22/2017

Several clinical trials are investigating the efficacy and safety of HDAC10 inhibitors in different cancer types.

Is HDAC10 exclusively associated with cancer, or does it have relevance in other diseases? 07/30/2016

While its primary focus is often on cancer, HDAC10 has also been implicated in other diseases, including neurological disorders.

Customer Reviews (3)

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Reviews
08/31/2020

    it has demonstrated remarkable effectiveness in ELISA experiments, showcasing its reliability and accuracy in detecting and quantifying specific targets.

    06/26/2019

      The reliable performance of the HDAC10 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

      09/12/2018

        the HDAC10 protein has proven to be an invaluable asset in protein electron microscopy structure analysis.

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