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Recombinant Human Interferon-β1b

Cat. No.: IFNB1-08H
Product Overview: Recombinant Human Interferon-β1b produced inE.coliis a single non-glycosylated polypeptide chain containing 165 amino acids and having a molecular mass of approximately 18.5 kDa.
Description: Interferon-beta is one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity. The synthesis of IFN-beta can be induced by common inducers of interferons, including viruses, double-stranded RNA, and micro-organisms. It is induced also by some cytokines such as TNF and IL-1.
Purity: >96% by SDS-PAGE and HPLC analyses.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in PBS, pH 7.4,containing 3% manitol.
Specific Activity: Fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay is less then 0.03 ng/ml, corresponding to a specific activity of 4.0 x107IU/ mg.
Endotoxin: Less than 1EU/μg of rHuIFN-β1b as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: IFNB1
Synonyms: interferon, beta 1, fibroblast; IFNB; IFB; IFF; IFNB_HUMAN; Interferon beta [Precursor]; IFN-beta; MGC96956; Fibroblast interferon; IFNB; IFNB1
Gene ID: 3456
mRNA Refseq: NM_002176
Protein Refseq: NP_002167
MIM: 147640
UniProt ID: P01574
Chromosome Location: 9p21
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Toll-like receptor signaling pathway.
Function: interferon-alpha/beta receptor binding

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