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Recombinant Human PNP, His-tagged

Cat.No.: PNP-150H
Product Overview: Recombinant Human PNP (Met1-Ser289) fused with 6­His tag at C­terminal, was expressed in E. coli.
Description: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Source: E. coli
Species: Human
Tag: His
Predicted N Terminal: Met1
Form: Supplied as a 0.2 µm filtered solution in Tris and NaCl.
Bio-activity: Measured by the phosphorolysis of 7-methyl-6-thioguanosine. The specific activity is >35,000 pmol/min/µg, as measured under the described conditions.
Molecular Mass: 33 kDa
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
Shipping: The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name: PNP purine nucleoside phosphorylase [ Homo sapiens (human) ]
Official Symbol: PNP
Synonyms: PNP; NP; PUNP; PRO1837; purine nucleoside phosphorylase; inosine phosphorylase; inosine-guanosine phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1
Gene ID: 4860
mRNA Refseq: NM_000270
Protein Refseq: NP_000261
MIM: 164050
UniProt ID: P00491
Chromosome Location: 14q13.1
Pathway: Metabolism; Metabolism of nucleotides; Nicotinate and nicotinamide metabolism
Function: drug binding; nucleoside binding; phosphate ion binding

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