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Recombinant Human TAF1, GST-tagged

Cat.No. : TAF1-165H
Product Overview : Recombinant Human TAF1 bromodomain 1 (1371-1496 aa) fused to a GST tag at the N-terminus
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Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.
Source : E. coli
Species : Human
Tag : GST
Form : Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Mass : 41.7 kDa (1371-1496 aa + NT GST Tag)
Purity : ≥95%
Storage : Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
Gene Name : TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [ Homo sapiens ]
Official Symbol : TAF1
Synonyms : TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; BA2R, CCG1, CCGS, dystonia 3 (with Parkinsonism) , DYT3, TAF2A, TATA box binding protein (TBP) associated factor, RNA polymerase II, A, 250kD; transcription initiation factor TFIID subunit 1; DYT3/TAF1; KAT4; NSCL2; TAFII250; TAFII-250; TAF(II)250; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S; transcription initiation factor TFIID 250 kDa subunit; OF; XDP; BA2R; CCG1; CCGS; DYT3; P250; TAF2A; N-TAF1;
Gene ID : 6872
mRNA Refseq : NM_004606
Protein Refseq : NP_004597
MIM : 313650
UniProt ID : P21675
Chromosome Location : Xq13.1
Pathway : Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem; HIV-1 Transcription Initiation, organism-specific biosystem;
Function : ATP binding; TBP-class protein binding; histone acetyl-lysine binding; histone acetyltransferase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein serine/threonine kinase activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; contributes_to transcription regulatory region DNA binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which TAF1 modulates the expression of specific sets of genes? 11/17/2022

TAF1 specifically modulates the expression of certain genes, impacting diverse cellular functions and processes.

How does TAF1 (TATA-Box Binding Protein Associated Factor 1) regulate transcription initiation by RNA polymerase II? 05/03/2022

TAF1 is pivotal in initiating transcription by RNA polymerase II, regulating the early steps of gene expression.

How does TAF1 contribute to the regulation of gene expression in response to cellular signals and stress? 09/30/2021

TAF1 responds to cellular signals and stress, adapting gene expression to meet cellular needs and challenges.

How does TAF1 influence chromatin remodeling and accessibility of DNA for transcription? 04/21/2021

TAF1 plays a role in chromatin remodeling, making DNA accessible for transcription and regulating gene activity.

How do alterations in TAF1 expression or function affect the cell cycle and apoptosis? 03/11/2019

Changes in TAF1 can influence key cellular processes like the cell cycle and programmed cell death.

What role does TAF1 play in the assembly and function of the transcription factor IID (TFIID) complex? 08/05/2018

TAF1 is integral to the TFIID complex, essential for accurate and efficient transcription initiation.

What is the impact of TAF1 mutations on neurodevelopmental disorders and intellectual disabilities? 02/06/2018

Mutations in TAF1 are linked to neurodevelopmental disorders, affecting brain development and function.

Customer Reviews (3)

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Reviews
10/20/2021

    Expertise in peptide synthesis, accelerates our peptide-based research.

    04/15/2019

      Swift protein quantification, improves data reliability in our work.

      11/26/2018

        Reliable protein crystallography, key for our structural biology research.

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