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Active Recombinant Human FGFR3, GST-tagged

Cat.No. : FGFR3-89H
Product Overview : Recombinant human FGFR3 (G697C) (397-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : The specific activity of FGFR3 (G697C) was determined to be 4.5 nmol/min/mg as per activity assay protocol.
Molecular Mass : ~73 kDa
AA Sequence : 397-end (G697C)
Purity : The purity of FGFR3 (G697C) was determined to be >95% by densitometry, approx.
Applications : Kinase Assay
Stability : 1 yr at –70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : FGFR3?fibroblast growth factor receptor 3 [?Homo sapiens(human) ]
Official Symbol : FGFR3
Synonyms : FGFR3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; fibroblast growth factor receptor 3; fibroblast growth factor receptor 3; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4; EC 2.7.10.1
Gene ID : 2261
mRNA Refseq : NM_000142
Protein Refseq : NP_000133
MIM : 134934
UniProt ID : P22607
Chromosome Location : 4p16.3
Pathway : Bladder cancer; Constitutive PI3K/AKT Signaling in Cancer; DAP12 signaling
Function : ATP binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FGFR3 testing assist in personalized medicine approaches? 12/13/2022

FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

Is FGFR3 testing routinely conducted in cancer diagnosis? 06/25/2022

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Can FGFR3 be a prognostic marker in cancer? 12/01/2016

Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

Are there targeted therapies based on FGFR3 in cancer treatment? 07/23/2016

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

How is FGFR3 targeted in cancer therapy? 03/13/2016

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

Customer Reviews (3)

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Reviews
01/13/2020

    Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

    03/26/2018

      Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

      08/29/2017

        Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

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