Fgfr3

  • Official Full Name

    fibroblast growth factor receptor 3

  • Overview

    This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
  • Synonyms

    FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Gallus gallus (Chicken)
  • Human
  • Human
  • Monkey
  • Mouse
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293E
  • HEK293T
  • Human
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • DDK
  • DDK|His
  • Fc
  • Fc Chimera
  • FC
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hFc
  • his
  • His (Fc)
  • Avi
  • His|Fc
  • His|HIgG
  • His|T7
  • B2M
  • Myc
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGFR3-700H Active Recombinant Human FGFR3, Fc Chimera Mammalian cells Fc Chimera
Human FGFR3-8320H Active Recombinant Human FGFR3 Mammalian cells N/A
Human FGFR3-610H Active Recombinant Human FGFR3, Fc-tagged, Biotinylated Human Cell Fc
Human FGFR3-609H Active Recombinant Human FGFR3, His-tagged, Biotinylated Human Cell His
Human FGFR3-87H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
Human FGFR3-611H Active Recombinant Human FGFR3, Fc-tagged Human Cell Fc
Human FGFR3-612H Active Recombinant Human FGFR3, His-tagged Human Cell His
Human FGFR3-89H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
Human FGFR3-88H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell GST
Human FGFR3-85H Active Recombinant Human FGFR3(447-761) Protein, N-His-tagged Sf21 His 447-761 aa
Human FGFR3-5003H Recombinant Human Fibroblast Growth Factor Receptor 3 Human N/A
Human FGFR3-315H Recombinant Human FGFR3, GST-tagged, Active Sf9 Insect Cell GST
Human FGFR3-78H Recombinant Human FGFR3, MYC/DDK-tagged HEK293 Myc/DDK
Human FGFR3-28836TH Recombinant Human FGFR3, Fc-tagged Fc
Human FGFR3-03H Recombinant Human Fibroblast Growth Factor Receptor 3, Fc-tagged Insect Cell Fc
Human FGFR3-5419H Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged Insect Cell his
Human FGFR3-59H Recombinant Human FGFR3 (V555M), GST-tagged Sf9 Insect Cell GST
Human FGFR3-227H Recombinant Human PLXNA1 Protein, His-tagged Sf9 Insect Cell GST
Human FGFR3-80H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
Human FGFR3-28835TH Recombinant Human FGFR3 N/A
Human FGFR3-779H Active Recombinant Human FGFR3 protein, Fc-tagged HEK293 Fc Glu23-Gly377
Human FGFR3-751H Active Recombinant Human FGFR3 protein, Fc-tagged HEK293 Fc Glu23-Gly375
Human FGFR3-119H Recombinant Human FGFR3 Protein, DDK-tagged Insect Cell DDK
Human FGFR3-79H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
Human FGFR3-752H Recombinant Human FGFR3 Protein, His-tagged, HPLC-verified HEK293 C-His Met1-Gly375
Human FGFR3-81H Recombinant Human FGFR3, DDK/His-tagged HEK293 DDK/His
Human FGFR3-46H Recombinant Human FGFR3 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human FGFR3-780H Recombinant Human FGFR3 Protein, His-tagged HEK293 His
Human FGFR3-1811H Recombinant Human FGFR3 protein, His & T7-tagged E.coli His/T7 Val166~Gly375 (Accession # P22607)
Human FGFR3-001H Recombinant Human FGFR3 Protein, Fc-His-tagged HEK293E FC/His 1-372
Human FGFR3-4136H Active Recombinant Human FGFR3 Protein, GST-tagged Insect Cell GST
Human FGFR3-4134H Recombinant Human FGFR3 Protein Wheat Germ N/A
Human FGFR3-4135H Recombinant Human FGFR3 Protein, Fc/His-tagged HEK293E Fc/His
Human FGFR3-612HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Asp127-Gly377.
Human FGFR3-4137H Recombinant Human FGFR3 Protein, GST-tagged Wheat Germ GST
Human FGFR3-607HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu23-Gly375
Human FGFR3-607H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi Glu23-Gly375
Human FGFR3-093HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Asp127-Gly375 .
Human FGFR3-207H Recombinant Human FGFR3 Protein, hIgG-His-tagged Insect Cell His/HIgG 23-375aa
Human FGFR3-608H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi Glu23 - Gly377
Human FGFR3-151H Recombinant Human FGFR3 Protein, His-tagged Human Cells His
Human FGFR3-093H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi It contains Asp127-Gly375 .
Human FGFR3-6072HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu23-Gly377
Human FGFR3-751HAF488 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 591
Human FGFR3-752HAF488 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 364
Human FGFR3-2916H Recombinant Human FGFR3 protein, His-tagged E.coli His 23-375aa
Human FGFR3-613H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 His-Avi It contains Asp127-Gly377.
Human FGFR3-779HAF488 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 593
Human FGFR3-780HAF488 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 366
Human FGFR3-2917H Recombinant Human FGFR3 protein, His-B2M-tagged E.coli His-B2M 397-806aa
Human FGFR3-779HAF555 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 593
Human FGFR3-752HAF555 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 364
Human FGFR3-751HAF555 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 591
Human FGFR3-5405H Recombinant Human FGFR3 protein, His-tagged Yeast His 23-375aa
Human FGFR3-780HAF555 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 366
Human FGFR3-751HAF647 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 591
Human FGFR3-752HAF647 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 364
Human FGFR3-6094HFL Recombinant Full Length Human FGFR3, Flag-tagged Mamanlian cells Flag
Human FGFR3-779HAF647 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 593
Human FGFR3-751HF Recombinant Human FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 591
Human FGFR3-752HF Recombinant Human FGFR3 Protein, His-tagged, FITC conjugated HEK293 His 364
Human FGFR3-93H Recombinant Human FGFR3 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Glu23-Gly375
Human FGFR3-780HAF647 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 366
Human FGFR3-779HF Recombinant Human FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 593
Human FGFR3-5406H Recombinant Human FGFR3 protein, His-tagged Yeast His 397-806aa
Human FGFR3-2668H Active Recombinant Human FGFR3 protein, hFc&His-tagged HEK293 hFc&His Glu23-Gly375
Human FGFR3-4114H Recombinant Human FGFR3 protein(Met1-Gly377), His-tagged HEK293 C-His Met1-Gly377
Human FGFR3-4893HF Recombinant Full Length Human FGFR3 Protein In Vitro Cell Free System 315 amino acids
Human FGFR3-4115H Recombinant Human FGFR3 Protein (Met1-Gly375), C-His tagged Mammalian cells C-His Met1-Gly375
Human FGFR3-187H-B Recombinant Human FGFR3 Protein Pre-coupled Magnetic Beads HEK293
Human FGFR3-780HF Recombinant Human FGFR3 Protein, His-tagged, FITC conjugated HEK293 His 366
Human FGFR3-187H Recombinant Human FGFR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fgfr3-536M Active Recombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged Mammalian cells Fc
Mouse Fgfr3-836M Active Recombinant Mouse Fgfr3 Protein, His & Fc-tagged HEK293 His/Fc
Mouse Fgfr3-836MF Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, FITC conjugated HEK293 His/Fc 595
Mouse Fgfr3-836MAF488 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 488 conjugated HEK293 His/Fc 595
Mouse Fgfr3-836MAF647 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 647 conjugated HEK293 His/Fc 595
Mouse Fgfr3-836MAF555 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 555 conjugated HEK293 His/Fc 595
Mouse Fgfr3-624M Active Recombinant Mouse Fgfr3 protein(Met1-Tyr367), His-tagged HEK293 C-His Met1-Tyr367
Mouse Fgfr3-1739M Recombinant Mouse Fibroblast Growth Factor Receptor 3 Mammalian cells N/A
Mouse Fgfr3-706M Recombinant Mouse Fgfr3 protein, His/Fc-tagged HEK293 His/Fc Met 1-Tyr 367
Mouse FGFR3-2596MCL Recombinant Mouse FGFR3 cell lysate Human Cell N/A
Mouse Fgfr3-10554M-B Recombinant Mouse Fgfr3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fgfr3-624MAF555 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 358
Mouse Fgfr3-10554M Recombinant Mouse Fgfr3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fgfr3-3003M Recombinant Mouse Fgfr3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Fgfr3-624MF Recombinant Mouse Fgfr3 Protein, His-tagged, FITC conjugated HEK293 His 358
Mouse Fgfr3-624MAF488 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 358
Mouse Fgfr3-624MAF647 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 358
Monkey FGFR3-1224CAF555 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 364
Monkey FGFR3-1224CAF488 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 364
Monkey FGFR3-204CAF647 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Gly375, 594
Monkey FGFR3-204CAF555 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Gly375, 594
Monkey FGFR3-1224CAF647 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 364
Monkey FGFR3-204CAF488 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Gly375, 594
Monkey FGFR3-1224CF Recombinant Cynomolgus FGFR3 Protein, His-tagged, FITC conjugated HEK293 His 364
Monkey FGFR3-204CF Recombinant Monkey FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Gly375, 594
Cynomolgus FGFR3-204C Active Recombinant Cynomolgus FGFR3 protein, hFc-tagged HEK293 hFc Met1-Gly375
Cynomolgus Monkey FGFR3-1224C Recombinant Cynomolgus FGFR3 Protein, His-tagged HEK293 His
Cynomolgus Monkey FGFR3-001CCL Recombinant Cynomolgus FGFR3 cell lysate Human Cell N/A
Gallus gallus (Chicken) RFL12486GF Recombinant Full Length Chicken Fibroblast Growth Factor Receptor 3(Fgfr3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-806)
Zebrafish FGFR3-9146Z Recombinant Zebrafish FGFR3 Mammalian Cell His
Chicken FGFR3-7058C Recombinant Chicken FGFR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Fgfr3 Related Signal Pathway

Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRPS6KA1;FGF11A;RAC3B;STMN1B;MAPK4;GRB2B;RAP1AB;FGF1A;MAP3K4
Ras signaling pathwayFASLG;RASSF5;SOS1;GNB3;KITLG;PLA2G10;PDGFD;VEGFA;ANGPT4
Rap signaling pathwayFGFR1;KITLG;Itgam&Itgb2;F2R;FGF7;LPAR3;KLK1B4;ANGPT4;CALM4
EndocytosisVPS37A;IL2RG;VPS37B;MVB12A;CHMP3;BF1;SNX3;ADRB1;LDLRAP1A
PIK-Akt signaling pathwayGSK3B;PHLPP1;SGK1;FGF6;KLK1B4;G6PC;IL7R;ITGA6;FN1
Signaling pathways regulating pluripotency of stem cellsSMAD3;MAP2K1;ISL1;WNT9A;KRAS;WNT10B;Fzd4;PCGF2;HESX1
Regulation of actin cytoskeletonCHRM2A;ARAF;RRAS;MYL10;FGF11A;MAPK1;ROCK2;RAC2;PIK3CD
Pathways in cancerSTAT3;PRKCG;SOS1;GNG2;FH;FZD9;GNA12;EGLN2;MECOM
MicroRNAs in cancerSLC45A3;PDGFB;DNMT3B;MDM2;IKBKB;PDGFA;FOXP1;TRP53;GLS2
Bladder cancerE2F3;MMP2;EGF;NRAS;TP53;DAPK1;UPK3A;CDKN2A;IL-8
Central carbon metabolism in cancerSIRT3;PIK3R2;HK1;G6PDX;SLC16A3;FGFR2;HK3;FLT3;PIK3CG

Fgfr3 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEPHA4;YES1;SRPK2;SCN8A;CSNK1D;MAT2A;CDC34;ITGB1BP3;PRKACG
fibroblast growth factor bindingTHBS1;S100A13;FIBPA;FGFRL1;FGFR4;HSPA9;FGFR3;Api5;RPS2
fibroblast growth factor-activated receptor activityFGFRL1;FGFR1;FGFR4;FGFR1B;FGFR1A;FGFR3;FGFR2
protein bindingTAGLN2;NEK11;GTF2H2C;ESRRG;DYNC1I2;MOBKL2B;ZNF10;RGS1;BCKDHA
protein tyrosine kinase activityKIT;DYRK2;EK1;EGFR;ERBB3A;PTK6B;FGFR3;TYK2;INSRB

Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.

FGF1; HSP90AB1; saicar; PKM; CTGF; abl-tide; HSPG2; CDC37; NDUFS6; HBZ; CHGB; KRT8; SLC25A6; HNRNPL; ATF3; CTSK

Gene Family

Cytokines

Research Area

Related articles

Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Kim, B; Wang, S; et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. ONCOGENE 34:1083-1093(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does FGFR3 testing assist in personalized medicine approaches? 12/13/2022

FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

Is FGFR3 testing routinely conducted in cancer diagnosis? 06/25/2022

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Can FGFR3 be a prognostic marker in cancer? 12/01/2016

Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

Are there targeted therapies based on FGFR3 in cancer treatment? 07/23/2016

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

How is FGFR3 targeted in cancer therapy? 03/13/2016

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

Customer Reviews (3)

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Reviews
01/13/2020

    Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

    03/26/2018

      Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

      08/29/2017

        Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

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