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Recombinant Human NIMA-related kinase 7, His-tagged

Cat.No. : NEK7-348H
Product Overview : NEK7, 1-302? aa, Human, His tag, E.coli?
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Description : NEK7 is protein kinase which plays an important role in mitotic cell cycle progression. It is required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. NEK7 is highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Recombinant human NEK7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol
Molecular Mass : 37 kDa (326aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMDEQSQ GMQGPPVPQF QPQKALRPDM GYNTLANFRI EKKIGRGQFS EVYRAACLLD GVPVALKKVQ IFDLMDAKAR ADCIKEIDLL KQLNHPNVIK YYASFIEDNE LNIVLELADA GDLSRMIKHF KKQKRLIPER TVWKYFVQLC SALEHMHSRR VMHRDIKPAN VFITATGVVK LGDLGLGRFF SSKTTAAHSL VGTPYYMSPE RIHENGYNFK SDIWSLGCLL YEMAALQSPF YGDKMNLYSL CKKIEQCDYP PLPSDHYSEE LRQLVNMCIN PDPEKRPDVT YVYDVAKRMH ACTASS
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ]
Official Symbol : NEK7
Synonyms : NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7;
Gene ID : 140609
mRNA Refseq : NM_133494
Protein Refseq : NP_598001
MIM : 606848
UniProt ID : Q8TDX7
Chromosome Location : 1q31.3
Function : ATP binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you elaborate on the specific functions of NEK7 in mitosis and its contributions to spindle assembly and chromosome segregation? 04/30/2022

NEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.

In neurological disorders, what evidence links NEK7 to disease pathology, and what cellular processes in the nervous system involve NEK7 activity? 11/09/2021

NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.

In cancer research, what evidence supports the involvement of NEK7 in tumorigenesis, and are there potential therapeutic targets associated with NEK7 dysregulation? 10/08/2020

NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.

How is NEK7 expression regulated, and what are the consequences of dysregulated NEK7 in cellular homeostasis and disease states? 06/19/2019

NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.

How does NEK7 participate in the innate immune response, particularly in the activation of the NLRP3 inflammasome, and what are the implications for inflammatory diseases? 05/02/2018

NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.

Customer Reviews (3)

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Reviews
08/17/2021

    Great service, exceptional product quality

    02/13/2020

      Our lab swears by this protein. Fast shipping is a definite bonus.

      11/01/2019

        Superb quality, accompanied by excellent service.

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