Recombinant Human NIMA-related kinase 7, His-tagged
Cat.No. : | NEK7-348H |
Product Overview : | NEK7, 1-302? aa, Human, His tag, E.coli? |
- Specification
- Gene Information
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Description : | NEK7 is protein kinase which plays an important role in mitotic cell cycle progression. It is required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. NEK7 is highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Recombinant human NEK7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol |
Molecular Mass : | 37 kDa (326aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMDEQSQ GMQGPPVPQF QPQKALRPDM GYNTLANFRI EKKIGRGQFS EVYRAACLLD GVPVALKKVQ IFDLMDAKAR ADCIKEIDLL KQLNHPNVIK YYASFIEDNE LNIVLELADA GDLSRMIKHF KKQKRLIPER TVWKYFVQLC SALEHMHSRR VMHRDIKPAN VFITATGVVK LGDLGLGRFF SSKTTAAHSL VGTPYYMSPE RIHENGYNFK SDIWSLGCLL YEMAALQSPF YGDKMNLYSL CKKIEQCDYP PLPSDHYSEE LRQLVNMCIN PDPEKRPDVT YVYDVAKRMH ACTASS |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name : | NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ] |
Official Symbol : | NEK7 |
Synonyms : | NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7; |
Gene ID : | 140609 |
mRNA Refseq : | NM_133494 |
Protein Refseq : | NP_598001 |
MIM : | 606848 |
UniProt ID : | Q8TDX7 |
Chromosome Location : | 1q31.3 |
Function : | ATP binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
NEK7-6011M | Recombinant Mouse NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEK7-3613R | Recombinant Rat NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEK7-588H | Recombinant Human NEK7 Protein, MYC/DDK-tagged | +Inquiry |
NEK7-3611H | Recombinant Human NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEK7-2818R | Recombinant Rhesus Macaque NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NEK7-654HCL | Recombinant Human NEK7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionNEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.
NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.
NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.
NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.
NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.
Customer Reviews (3)
Write a reviewGreat service, exceptional product quality
Our lab swears by this protein. Fast shipping is a definite bonus.
Superb quality, accompanied by excellent service.
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