"IGFBP1" Related Products


Recombinant Human IGFBP1, His-tagged

Cat.No.: IGFBP1-39H
Product Overview: Recombinant Human IGFBP1 was produced from yeast with the N-terminal His-tag.
Description: IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family ,a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP-1 has been shown to modify the short-term effects of IGFs. Acute and chronic elevations in plasma insulin suppress the hepatic production and the circulating level of IGFBP-1, which, in turn, serve to increase the bioavailability of free IGF-I. There is growing evidence that IGFBP-1 and the IGF/IGFBP system may form an important link between the development of hyperinsulinemia/insulin resistance and the development of cardiovascular disease. In the circulation, IGFBP-1 may prevent the adverse IGF-mediated remodeling effect on the vasculature.
Source: E. coli
Species: Human
Tag: His
Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
Molecular Mass: 16 kDa
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -20℃ to -94℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.
Gene Name: IGFBP1 insulin-like growth factor binding protein 1 [ Homo sapiens ]
Official Symbol: IGFBP1
Synonyms: IGFBP1; insulin-like growth factor binding protein 1; IBP1; insulin-like growth factor-binding protein 1; AFBP; alpha pregnancy associated endometrial globulin; amniotic fluid binding protein; binding protein 25; binding protein 26; binding protein 28; growth hormone independent binding protein; hIGFBP 1; IGF binding protein 1; IGF BP25; placental protein 12; PP12; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; IGF-binding protein 1; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin; IGF-BP25; hIGFBP-1;
Gene ID: 3484
mRNA Refseq: NM_000596
Protein Refseq: NP_000587
MIM: 146730
UniProt ID: P08833
Chromosome Location: 7p13-p12
Pathway: Activation of Genes by ATF4, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; PERK regulated gene expression, organism-specific biosystem;
Function: insulin-like growth factor binding;

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