Active Recombinant Human CDK5 & CDK5R1 protein, GST-tagged
Cat.No. : | CDK5/CDK5R1-256H |
Product Overview : | Recombinant full-length human CDK5 and human p35 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Species : | Human |
Source : | Insect Cells |
Tag : | GST |
Description : | CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction. |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 180 nmol/min/mg |
Purity : | >85% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1 yr at -70 centigrade from date shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | CDK5 cyclin-dependent kinase 5 [ Homo sapiens ] |
Official Symbol | CDK5 |
Synonyms | CDK5; cyclin-dependent kinase 5; PSSALRE; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; |
Gene ID | 1020 |
mRNA Refseq | NM_004935 |
Protein Refseq | NP_004926 |
MIM | 123831 |
UniProt ID | Q00535 |
Chromosome Location | 7q36 |
Pathway | Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CRMPs in Sema3A signaling, organism-specific biosystem; Cocaine addiction, organism-specific biosystem; |
Function | ATP binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; acetylcholine receptor activator activity; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; |
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CDK5/CDK5R1-256H | Active Recombinant Human CDK5 & CDK5R1 protein, GST-tagged | +Inquiry |
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Not For Human Consumption!
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