Recombinant Human CDK5 & CDK5R1 protein, GST-tagged CDK5/CDK5R1-256H

Specification Gene Information

Cat.No. :	CDK5/CDK5R1-256H
Product Overview :	Recombinant full-length human CDK5 and human p35 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description :	CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
Source :	Insect cells
Species :	Human
Tag :	GST
Form :	50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity :	180 nmol/min/mg
Purity :	>85%
Applications :	Kinase Assay, Western Blot
Stability :	1 yr at -70 centigrade from date shipment
Storage :	Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration :	0.1μg/μl

Gene Name :	CDK5 cyclin-dependent kinase 5 [ Homo sapiens ]
Official Symbol :	CDK5
Synonyms :	CDK5; cyclin-dependent kinase 5; PSSALRE; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit;
Gene ID :	1020
mRNA Refseq :	NM_004935
Protein Refseq :	NP_004926
MIM :	123831
UniProt ID :	Q00535
Chromosome Location :	7q36
Pathway :	Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CRMPs in Sema3A signaling, organism-specific biosystem; Cocaine addiction, organism-specific biosystem;
Function :	ATP binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; acetylcholine receptor activator activity; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity;

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