"HDAC3" Related Products

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Recombinant Human Histone Deacetylase 3, His GST-tagged

Cat. No. : HDAC3-394H
Product Overview : Full Length Human HDAC3– Class I, 53kD with his His & GST tag.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Source : HDAC3 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity : Purified, active enzyme.
Purification Procedure : Ni2+ Affinity Column & Glutathione
Activity : 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life : >6 months from date of shipment
Buffer Composition : 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
Storage : –80°C
Gene Name : HDAC3 histone deacetylase 3 [ Homo sapiens ]
Synonyms : HDAC3; RPD3; HD3; RPD3-2; histone deacetylase 3; EC 3.5.1.98; SMAP45.
Gene ID : 8841
mRNA Refseq : NM_003883
Protein Refseq : NP_003874
MIM : 605166
UniProt ID : O15379
Chromosome Location : 5q31
Pathway : Signalling by NGF
Function : DNA binding; histone deacetylase activity; hydrolase activity; transcription factor binding

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