Expand| Cat. No. : | RPLP0-198H |
| Product Overview : | Recombinant Human Ribosomal Phosphoprotein P0 (His-tagged) produced inSf9is a glycosylated, polypeptide chain. The protein has a molecular mass of 35,096 dalton. The protein is purified by proprietary chromatographic techniques. |
| Description : | The ribosomal phosphoproteins, also called P protein antigens, are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa, P1 (19 kDa) and P2 (17 kDa). Autoantibodies against ribosomal P proteins are present in 10 % of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies. |
| Source : | Sf9 insect cells. |
| Formulation : | Recombinant Human Ribosomal Phosphoprotein P0 is supplied at a of 0.9mg/ml in20mM HEPES buffer pH-7.5, 0.01 mM EDTA. 0.02% SDS. |
| Immunological Functions : | 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels. |
| Applications : | Western-Blot with monoclonal anti-hexa-His-tag antibody & SLE sera (Systemic Lupus Erythematodes Disease). |
| Purity : | Greater than 80% (SDS-PAGE). |
| Coating Concentration : | 0.3-0.7 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination. |
| Storage Conditions : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Gene Name : | RPLP0 ribosomal protein, large, P0 [ Homo sapiens ] |
| Synonyms : | RPLP0; ribosomal protein, large, P0; P0; L10E; RPP0; PRLP0; MGC88175; MGC111226; RPLP0;60S acidic ribosomal protein P0; acidic ribosomal phosphoprotein P0; ribosomal protein P0; ribosomal protein, large, P0 |
| Gene ID : | 6175 |
| mRNA Refseq : | NM_001002 |
| Protein Refseq : | NP_000993 |
| MIM : | 180510 |
| UniProt ID : | P05388 |
| Chromosome Location : | 12q24.2 |
| Pathway : | Ribosome; Gene Expression; Influenza Infection; Metabolism of proteins |
| Function : | RNA binding;protein binding;structural constituent of ribosome |
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