Recombinant Human Activin A Receptor, Type I, Fc Chimera ACVR1-489H

Recombinant Human Activin A Receptor, Type I, Fc Chimera

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Recombinant Human Activin A Receptor, Type I, Fc Chimera

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Cat. No. : ACVR1-489H
Product Overview : Recombinant human activin A receptor, Type I encoding the signal peptide and extracellular domain of human activin A receptor, Type I (aa 1-123) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modifiedhuman 293 cells.
Description : Activin A receptor, type I, Fc Chimera (also known as ACVR1 or ALK-2) is an activin type I receptor. The activin type I receptors transducer signals for a variety of members of the transforming growth factor (TGF) beta superfamily of ligands. This family of cytokine and hormones include activin, anti-mϋlle rian hormone (AMH), bone morphogenetic proteins (BMPs) and nodal. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type II receptor, which recruits and trans-phosphorylates a type I receptor.
Source : Human 293 cells.
Amino Acid Sequence : MEDEKPKVNPKLYMC VCEGLSCGNEDHCEG QQCFSSLSINDGFHV YQKGCFQVYEQGKMT CKTPPSPGQAVECCQ GDWCNRNITAQLPTK GKSFPGTQNFHLEGS SNTKVDKKVEPKSCD KTHTCPPCPAPELLG GPSVFLFPPKPKDTL MISRTPEVTCVVVDV SHEDPEVKFNWYVDG VEVHNAKTKPREEQY NSTYRVVSVLTVLHQ DWLNGKEYKCKVSNK ALPAPIEKTISKAKG QPREPQVYTLPPSRD ELTKNQVSLTCLVKG FYPSDIAVEWESNGQ PENNYKTTPPVLDSD GSFFLYSKLTVDKSR WQQGNVFSCSVMHEA LHNHYTQKSLSLSPG K.
Molecular Mass : Under reducing conditions Activin A Receptor, Type I, Fc Chimera migrates as a broad band between 40 and 48 kDa on SDS-PAGE due to post-translational modifications, in particular glycosylation.
PI : Activin A Receptor, Type I, Fc Chimera separates into a number of glycoforms with an observed pI between 5.5 and 8.5 on 2D PAGE due to post-translational modifications, in particular glycosylation.
% Carbohydrate : Purified Activin A Receptor, Type I, Fc Chimera consists of 3-20% carbohydrate by weight.
Glycosylation : Activin A Receptor, Type I, Fc Chimera contains N-linked oligosaccharides and may contain O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name : VR1 activin A receptor, type I [ Homo sapiens ]
Synonyms : ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
UniProt ID : Q04771
Chromosome Location : 2q23-q24
MIM : 102576
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding

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