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Recombinant Human Activin A Receptor, Type I, Fc Chimera

Cat.No. : ACVR1-489H
Product Overview : Recombinant human activin A receptor, Type I encoding the signal peptide and extracellular domain of human activin A receptor, Type I (aa 1-123) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modifiedhuman 293 cells.
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Cat. No. : ACVR1-489H
Description : Activin A receptor, type I, Fc Chimera (also known as ACVR1 or ALK-2) is an activin type I receptor. The activin type I receptors transducer signals for a variety of members of the transforming growth factor (TGF) beta superfamily of ligands. This family of cytokine and hormones include activin, anti-mϋlle rian hormone (AMH), bone morphogenetic proteins (BMPs) and nodal. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type II receptor, which recruits and trans-phosphorylates a type I receptor.
Source : Human 293 cells.
Amino Acid Sequence : MEDEKPKVNPKLYMCVCEGLSCGNE DHCEGQQCFSSLSINDGFHVYQKGC FQVYEQGKMTCKTPPSPGQAVECCQ GDWCNRNITAQLPTKGKSFPGTQNF HLEGSSNTKVDKKVEPKSCDKTHTC PPCPAPELLGGPSVFLFPPKPKDTL MISRTPEVTCVVVDVSHEDPEVKFN WYVDGVEVHNAKTKPREEQYNSTYR VVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTL PPSRDELTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSD GSFFLYSKLTVDKSRWQQGNVFSCS VMHEALHNHYTQKSLSLSPGK.
Molecular Mass : Under reducing conditions Activin A Receptor, Type I, Fc Chimera migrates as a broad band between 40 and 48 kDa on SDS-PAGE due to post-translational modifications, in particular glycosylation.
PI : Activin A Receptor, Type I, Fc Chimera separates into a number of glycoforms with an observed pI between 5.5 and 8.5 on 2D PAGE due to post-translational modifications, in particular glycosylation.
% Carbohydrate : Purified Activin A Receptor, Type I, Fc Chimera consists of 3-20% carbohydrate by weight.
Glycosylation : Activin A Receptor, Type I, Fc Chimera contains N-linked oligosaccharides and may contain O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name : VR1 activin A receptor, type I [ Homo sapiens ]
Synonyms : ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
UniProt ID : Q04771
Chromosome Location : 2q23-q24
MIM : 102576
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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