Recombinant Human MCAM protein, Fc-tagged
Cat.No. : | MCAM-615H |
Product Overview : | Recombinant Human MCAM (Val24-Gly559) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Val24 |
Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 86.2 kDa. The protein migrates as 115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Val24-Gly559 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | MCAM |
Official Symbol : | MCAM |
Synonyms : | MCAM; melanoma cell adhesion molecule; cell surface glycoprotein MUC18; CD146; Gicerin; MUC18; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen |
Gene ID : | 4162 |
mRNA Refseq : | NM_006500 |
Protein Refseq : | NP_006491 |
MIM : | 155735 |
UniProt ID : | P43121 |
Products Types
◆ Recombinant Protein | ||
MCAM-378H | Recombinant Human MCAM Protein, His-tagged | +Inquiry |
MCAM-379H | Recombinant Human MCAM Protein, Fc-tagged | +Inquiry |
MCAM-697H | Recombinant Human MCAM Protein, MYC/DDK-tagged | +Inquiry |
MCAM-3268R | Recombinant Rat MCAM Protein, His (Fc)-Avi-tagged | +Inquiry |
MCAM-1380H | Recombinant Human MCAM Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MCAM-1713MCL | Recombinant Mouse MCAM cell lysate | +Inquiry |
MCAM-2742HCL | Recombinant Human MCAM cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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