"Fgfr3" Related Products

Expand
Expand

Recombinant Mouse Fgfr3 protein, His/Fc-tagged

Cat.No.: Fgfr3-706M
Product Overview: Recombinant Mouse Fgfr3(Met 1-Tyr 367) fused fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus was expressed in HEK293.
Description: FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.
Source: HEK293
Species: Mouse
Tag: His/Fc
Predicted N Terminal: Glu 21
Form: Lyophilized from sterile PBS, pH 7.41. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.
Molecular Mass: The recombinant mouse FGFR3/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 595 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FGFR3/Fc monomer is approximately 100-110 kDa due to glycosylation.
Protein length: Met 1-Tyr 367
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Purity: > 92 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus ]
Official Symbol: Fgfr3
Synonyms: FGFR3; fibroblast growth factor receptor 3; heparin-binding growth factor receptor; FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3;
Gene ID: 14184
mRNA Refseq: NM_001163215
Protein Refseq: NP_001156687
MIM:
UniProt ID:
Chromosome Location: 5 17.83 cM; 5 B
Pathway: Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; ESC Pluripotency Pathways, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem;
Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.