"NCOA1" Related Products

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Recombinant Human NCOA1, Receptor Interacting Domain, Non-tagged

Cat. No.: NCOA1-1161H
Description: Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptors and has been previously used in assays detecting liganddependent receptor-cofactor interactions. This protein does not contain any tag and will be useful for assays where a native untagged protein is desired.
Source: E. coli.
Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
Purity: > 95% by SDS-PAGE.
Activity: 100 ng are sufficient for a protein-protein interaction assay.
Application: Recombinant SCR1 (627-786) can be used for proteinprotein interaction assays.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name: NCOA1 nuclear receptor coactivator 1 [ Homo sapiens ]
Synonyms: NCOA1; nuclear receptor coactivator 1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74; MGC129719; MGC129720; Hin-2 protein; OTTHUMP00000155181; OTTHUMP00000155182; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; EC 2.3.1.48; OTTHUMP00000155183; NCoA-1; RIP160; SRC-1; Protein Hin-2; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; nuclear receptor coactivator 1
Gene ID: 8648
mRNA Refseq: NM_003743
Protein Refseq: NP_003734
MIM: 602691
UniProt ID: Q15788
Chromosome Location: 2p23
Function: DNA binding; acyltransferase activity; androgen receptor binding; chromatin binding; histone acetyltransferase activity; nuclear hormone receptor binding; protein N-terminus binding; signal transducer activity; transcription coactivator activity; transcription regulator activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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