Recombinant Human DAPK1, GST-tagged, Active

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Recombinant Human DAPK1, GST-tagged, Active

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Cat. No. : DAPK1-289H
Product Overview : Recombinant human DAPK1 (1-363) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 71kDa.
Description : Death-associated protein kinase 1 (DAPK1) is a positive mediator of apoptosis induced by γ-interferon. Activation of DAPK occurs via dephosphorylation of Ser-308 and subsequent association of calcium/calmodulin. DAPK is rapidly dephosphorylated in response to tumor necrosis factor or ceramide and then subsequently degraded via proteasome activity. The decline in DAPK expression is paralleled with increased caspase activity and cell apoptosis. Studies suggest that the apoptosis regulatory activities mediated by DAPK are controlled both by phosphorylation status and protein stability.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 1-363.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1ig1. :

Gene Name : DAPK1 death-associated protein kinase 1 [ Homo sapiens ]
Synonyms : DAPK1; death-associated protein kinase 1; DAPK; DKFZp781I035; EC 2.7.11.1; death associated protein kinase 1
Gene ID : 1612
mRNA Refseq : NM_004938
Protein Refseq : NP_004929
MIM : 600831
UniProt ID : P53355
Chromosome Location : 9q34.1
Pathway : Bladder cancer; Pathways in cancer
Function : ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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