Recombinant Human BMX
Cat.No. : | BMX-26755TH |
Product Overview : | Recombinant full length BMX protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 110 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Tissue specificity : | Preferentially expressed in epithelial and endothelial cells. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.Contains 1 Btk-type zinc finger.Contains 1 PH domain.Contains 1 protein kinase domain.Contains 1 SH2 domain. |
Gene Name : | BMX BMX non-receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | BMX |
Synonyms : | BMX; BMX non-receptor tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; ETK; PSCTK3; |
Gene ID : | 660 |
mRNA Refseq : | NM_001721 |
Protein Refseq : | NP_001712 |
MIM : | 300101 |
Uniprot ID : | P51813 |
Chromosome Location : | Xp22.2 |
Pathway : | Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Bmx-716M | Recombinant Mouse Bmx Protein, MYC/DDK-tagged | +Inquiry |
BMX-0751H | Recombinant Human BMX Protein (E411-H675), Tag Free | +Inquiry |
BMX-452H | Recombinant Human BMX Protein, His (Fc)-Avi-tagged | +Inquiry |
BMX-0752H | Recombinant Human BMX Protein (E411-H675), His tagged | +Inquiry |
Bmx-1530M | Recombinant Mouse Bmx protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
BMX-8427HCL | Recombinant Human BMX 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionBMX interacts with Tec family kinases to regulate immune cell signaling, affecting immune responses.
Inhibition of BMX reduces angiogenesis in tumor models, suggesting a role in tumor growth and metastasis.
Targeting BMX in cardiovascular diseases offers potential therapeutic benefits, possibly impacting vascular remodeling and function.
BMX kinase substrates vary by cell type, impacting diverse signaling pathways related to cell growth and survival.
BMX expression differs in cancerous tissues, with heightened levels in certain breast and prostate cancers, indicating a potential role in tumor progression.
BMX is involved in regulating inflammatory responses, playing a significant role in autoimmune disease mechanisms.
Phosphorylation alters BMX activity and stability, influencing its function in cellular signaling processes.
Customer Reviews (3)
Write a reviewAccurate mass spectrometry analysis; essential for proteomics research.
Reliable western blot results; a staple for our lab work.
Precise protein quantification; vital for our research projects.
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