||Recombinant full length BMX protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 110 kDa.
||This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
||Preferentially expressed in epithelial and endothelial cells.
||Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.Contains 1 Btk-type zinc finger.Contains 1 PH domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.