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Recombinant Human BMX

Cat.No. : BMX-26755TH
Product Overview : Recombinant full length BMX protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 110 kDa.
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Description : This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Tissue specificity : Preferentially expressed in epithelial and endothelial cells.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.Contains 1 Btk-type zinc finger.Contains 1 PH domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.
Gene Name : BMX BMX non-receptor tyrosine kinase [ Homo sapiens ]
Official Symbol : BMX
Synonyms : BMX; BMX non-receptor tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; ETK; PSCTK3;
Gene ID : 660
mRNA Refseq : NM_001721
Protein Refseq : NP_001712
MIM : 300101
Uniprot ID : P51813
Chromosome Location : Xp22.2
Pathway : Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem;
Function : ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does BMX interact with other members of the Tec family kinases in immune cell signaling? 04/23/2022

BMX interacts with Tec family kinases to regulate immune cell signaling, affecting immune responses.

What are the effects of BMX inhibition on the angiogenesis process in tumor models? 08/15/2021

Inhibition of BMX reduces angiogenesis in tumor models, suggesting a role in tumor growth and metastasis.

What are the potential therapeutic applications of targeting BMX in cardiovascular diseases? 04/29/2021

Targeting BMX in cardiovascular diseases offers potential therapeutic benefits, possibly impacting vascular remodeling and function.

What are the specific substrates of BMX kinase in different cell types and how do they influence cell signaling pathways? 09/08/2020

BMX kinase substrates vary by cell type, impacting diverse signaling pathways related to cell growth and survival.

How does the expression of BMX vary in normal versus cancerous tissues, particularly in breast and prostate cancers? 08/26/2020

BMX expression differs in cancerous tissues, with heightened levels in certain breast and prostate cancers, indicating a potential role in tumor progression.

What role does BMX play in the regulation of inflammatory responses in autoimmune diseases? 10/28/2018

BMX is involved in regulating inflammatory responses, playing a significant role in autoimmune disease mechanisms.

How does phosphorylation affect the activity and stability of BMX in cellular contexts? 07/03/2018

Phosphorylation alters BMX activity and stability, influencing its function in cellular signaling processes.

Customer Reviews (3)

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Reviews
02/22/2022

    Accurate mass spectrometry analysis; essential for proteomics research.

    10/02/2021

      Reliable western blot results; a staple for our lab work.

      10/15/2018

        Precise protein quantification; vital for our research projects.

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