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Recombinant Human BPGM, His-tagged

Cat.No.: BPGM-27666TH
Product Overview: Recombinant full length Human BPGM with a C terminal His tag. 267 amino acids with a predicted MWt 31 kDa including tag.
Description: 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Protein length: 259 amino acids
Conjugation: HIS
Molecular Weight: 31.000kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol
Storage: Please see Notes section
Sequences of amino acids: MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL NRSIHTAWLI LEELGQEWVP VESSWRLNERHYGALIGLNR EQMALNHGEE QVRLWRRSYN VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA IQAAIKKVED QGKVKQAKKL EHHHHHH
Sequence Similarities: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Gene Name: BPGM 2,3-bisphosphoglycerate mutase [ Homo sapiens ]
Official Symbol: BPGM
Synonyms: BPGM; 2,3-bisphosphoglycerate mutase; bisphosphoglycerate mutase;
Gene ID: 669
mRNA Refseq: NM_001724
Protein Refseq: NP_001715
MIM: 613896
Uniprot ID: P07738
Chromosome Location: 7q31-q34
Pathway: Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function: bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; hydrolase activity; isomerase activity; phosphoglycerate mutase activity;

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