Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Human CCNE1

Cat.No. : CDK2-30287TH
Product Overview : Recombinant full length Human CDK2 and CCNE1 with N-terminal proprietary tags co-expressed in a Baculovirus infected Sf9 cell expression system, MWt 58 and 73 kDa respectively.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]
Official Symbol : CDK2
Synonyms : CDK2; cyclin-dependent kinase 2;
Gene ID : 1017
mRNA Refseq : NM_001798
Protein Refseq : NP_001789
MIM : 116953
Uniprot ID : P24941
Chromosome Location : 12q13
Pathway : APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem;
Function : ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; contributes_to histone kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of CDK2 in cell cycle regulation? 07/10/2021

CDK2 is crucial for driving cells through the G1/S and S phases of the cell cycle.

What role does CDK2 play in cellular response to DNA damage? 05/04/2020

CDK2 helps in cell cycle arrest to allow DNA repair, preventing mutation accumulation.

What are the key regulatory mechanisms controlling CDK2 activity? 03/08/2020

CDK2 activity is controlled by cyclins, CDK inhibitors, and phosphorylation status.

How is dysregulation of CDK2 implicated in cancer development? 01/23/2020

CDK2 dysregulation can lead to uncontrolled cell proliferation, contributing to cancer.

Are there existing or potential therapeutic strategies targeting CDK2? 01/08/2020

Targeting CDK2 with specific inhibitors is explored as a potential cancer therapy strategy.

How is CDK2 activity linked to cell cycle checkpoints? 04/06/2019

It is integral to cell cycle checkpoints ensuring DNA integrity before replication.

How does CDK2 contribute to DNA replication? 02/13/2018

It phosphorylates proteins necessary for DNA replication initiation.

Customer Reviews (3)

Write a review
Reviews
04/14/2022

    Product met expectations, happy.

    03/22/2022

      High quality, reliable results.

      05/31/2021

        Outstanding performance, highly recommend.

        Ask a Question for All CDK2 Products

        Required fields are marked with *

        My Review for All CDK2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends