Native Human CTSL1

• Cat.No.: CTSL1-27406TH
• Product Overview: Full length native Human Cathepsin L purified from Human liver, 25-29kDa.

Specification

• Description: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
• Biological activity: Activity: Greater than 1 unit per mg of protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Z-Phe-Arg-AFC per minute at 25°C using 400 mM Na Acetate, pH 5.5 with 4 mM EDTA and 8 mM DTT as the activation buffer in the
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 400mM Sodium chloride, 20 mM Malonate, 1mM EDTA, pH 5.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase C1 family.

Gene Information

• Gene Name: CTSL1 cathepsin L1 [ Homo sapiens ]
• Official Symbol: CTSL1
• Synonyms: CTSL1; cathepsin L1; cathepsin L , CTSL; FLJ31037
• Gene ID: 1514
• mRNA Refseq: NM_001912
• Protein Refseq: NP_001903
• MIM: 116880
• Uniprot ID: P07711
• Chromosome Location: 9q21.33
• Pathway: Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Phagosome, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; histone binding; peptidase activity; protein binding