Recombinant Human EEF2K EEF2K-27779TH

Recombinant Human EEF2K

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Recombinant Human EEF2K

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Cat.No. : EEF2K-27779TH
Product Overview : Recombinant full length human EEF2K with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; amino acids 1-725, 125kDa.
Description : This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
Biological activity : Specific activity of EEF2K was determined to be 50nmol/min/mg as per activity assay protocol
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Alpha-type protein kinase family.Contains 1 alpha-type protein kinase domain.
Gene Name : EEF2K eukaryotic elongation factor-2 kinase [ Homo sapiens ]
Official Symbol : EEF2K
Synonyms : EEF2K; eukaryotic elongation factor-2 kinase; eukaryotic elongation factor 2 kinase; eEF 2K;
Gene ID : 29904
mRNA Refseq : NM_013302
Protein Refseq : NP_037434
MIM : 606968
Uniprot ID : O00418
Chromosome Location : 16p12
Pathway : IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem; PI3K Cascade, organism-specific biosystem; PKB-mediated events, organism-specific biosystem;
Function : ATP binding; calcium ion binding; calmodulin binding; elongation factor-2 kinase activity; nucleotide binding;

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