Recombinant Human EPHB3

• Cat.No.: EPHB3-28578TH
• Product Overview: Recombinant fusion protein, corresponding to C terminal amino acids 585-998 of Human Eph receptor B3, expressed by baculovirus in Sf9 insect cells using an N-terminal tag.

Specification

• Description: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
• Tissue specificity: Ubiquitous.
• Biological activity: Specific activity 26 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain.

Gene Information

• Gene Name: EPHB3 EPH receptor B3 [ Homo sapiens ]
• Official Symbol: EPHB3
• Synonyms: EPHB3; EPH receptor B3; EphB3 , ETK2; ephrin type-B receptor 3; Hek2; Tyro6
• Gene ID: 2049
• mRNA Refseq: NM_004443
• Protein Refseq: NP_004434
• MIM: 601839
• Uniprot ID: P54753
• Chromosome Location: 3q21-qter
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHB forward signaling, organism-specific biosystem; EphrinB-EPHB pathway, organism-specific biosystem
• Function: ATP binding; axon guidance receptor activity; ephrin receptor activity; nucleotide binding; receptor activity