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Recombinant Human ITK

Cat.No. : ITK-29869TH
Product Overview : Recombinant fragment corresponding to amino acids 352-620 of human ITK with N terminal proprietary tag expressed in Sf9 cells, 53 kDa.
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  • Gene Information
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Description : This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Tissue specificity : T-cell lines and natural killer cell lines.
Biological activity : Specific Activity: 58 nmol/min/mg
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.Contains 1 Btk-type zinc finger.Contains 1 PH domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.
Gene Name : ITK IL2-inducible T-cell kinase [ Homo sapiens ]
Official Symbol : ITK
Synonyms : ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2;
Gene ID : 3702
mRNA Refseq : NM_005546
Protein Refseq : NP_005537
MIM : 186973
Uniprot ID : Q08881
Chromosome Location : 5q31-q32
Pathway : Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem;
Function : ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the significance of ITK in allergic and autoimmune diseases, and how does it contribute to immune dysregulation in these conditions? 01/10/2022

ITK's involvement in Th2 cell differentiation links it to allergic diseases. Dysregulation of ITK is implicated in autoimmune diseases, influencing aberrant T-cell responses and immune system dysfunction.

Can you discuss the role of ITK in the context of immunodeficiency disorders, and how genetic variations impact its function? 12/01/2021

Deficiencies in ITK function are associated with immunodeficiency disorders. Genetic variations in ITK may compromise its kinase activity, leading to impaired T-cell signaling and immune responses.

What is the primary role of the ITK protein in T-cell signaling, and how does it contribute to immune responses? 10/17/2020

ITK is a tyrosine kinase involved in T-cell signaling, specifically in the activation of T-cell receptors. It plays a critical role in the regulation of immune responses and T-cell-mediated immunity.

Can you discuss the molecular mechanisms by which ITK is activated and its downstream signaling pathways in T cells? 02/27/2019

ITK is activated by phosphorylation and participates in downstream signaling pathways, including the PLCγ1 pathway, leading to the mobilization of calcium ions and activation of NFAT transcription factors.

How does ITK participate in the regulation of immune synapse formation, and what are the implications for T-cell activation and effector functions? 09/03/2018

ITK contributes to immune synapse formation by mediating cytoskeletal changes and promoting T-cell receptor clustering. This influences T-cell activation and the subsequent effector functions.

Customer Reviews (3)

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Reviews
06/28/2021

    Research-grade excellence. This product has simplified our experiments, and the quality is unmatched.

    06/15/2020

      The shipping speed surprised me! Got what I needed for our experiments right on schedule.

      10/06/2018

        Customer service that goes above and beyond. They truly understand our lab's needs

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