Recombinant Human MECP2
Cat.No. : | MECP2-27384TH |
Product Overview : | Recombinant fragment corresponding to amino acids 81-170 of Human MeCP2 with a proprietary tag; Predicted MWt 35.53 kDa including tag. |
- Specification
- Gene Information
- Related Products
Description : | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Present in all adult somatic tissues tested. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | PKQRRSIIRDRGPMYDDPTLPEGWT RKLKQRKSGRSAGKYDVYLINPQGK AFRSKVELIAYFEKVGDTSLDPNDF DFTVTGRGSPSRREQ |
Sequence Similarities : | Contains 2 A.T hook DNA-binding domains.Contains 1 MBD (methyl-CpG-binding) domain. |
Gene Name : | MECP2 methyl CpG binding protein 2 (Rett syndrome) [ Homo sapiens ] |
Official Symbol : | MECP2 |
Synonyms : | MECP2; methyl CpG binding protein 2 (Rett syndrome); mental retardation, X linked 16 , mental retardation, X linked 79 , MRX16, MRX79, RTT; methyl-CpG-binding protein 2; |
Gene ID : | 4204 |
mRNA Refseq : | NM_001110792 |
Protein Refseq : | NP_001104262 |
MIM : | 300005 |
Uniprot ID : | P51608 |
Chromosome Location : | Xq28 |
Function : | DNA binding; double-stranded methylated DNA binding; protein N-terminus binding; protein binding; protein domain specific binding; |
Products Types
◆ Recombinant Protein | ||
MECP2-428C | Recombinant Cynomolgus Monkey MECP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MECP2-5439M | Recombinant Mouse MECP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MECP2-1549H | Recombinant Human MECP2 Protein, His-tagged | +Inquiry |
MECP2-3289R | Recombinant Rat MECP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MECP2-334H | Recombinant Human MECP2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MECP2-4395HCL | Recombinant Human MECP2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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