"NR1H2" Related Products

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Recombinant Human NR1H2

Cat.No.: NR1H2-27982TH
Product Overview: Recombinant full length human LXR beta with proprietary tag.
Description: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al.
Source: E. coli
Tissue specificity: Ubiquitous.
Biological activity: 1 unit equals 1 nanogram of purified protein.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.
Gene Name: NR1H2 nuclear receptor subfamily 1, group H, member 2 [ Homo sapiens ]
Official Symbol: NR1H2
Synonyms: NR1H2; nuclear receptor subfamily 1, group H, member 2; ubiquitously expressed nuclear receptor , UNR; oxysterols receptor LXR-beta; liver X receptor beta; LXR b; NER; NER I; RIP15;
Gene ID: 7376
mRNA Refseq: NM_007121
Protein Refseq: NP_009052
MIM: 600380
Uniprot ID: P55055
Chromosome Location: 19q13.3
Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem;
Function: DNA binding; ligand-dependent nuclear receptor activity; metal ion binding; protein binding; receptor activity;

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