Recombinant Human TBK1

• Cat.No.: TBK1-27920TH
• Product Overview: Recombinant full length human NAK with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; amino acids 1-729, 105kDa.

Specification

• Description: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
• Tissue specificity: Ubiquitous with higher expression in testis.
• Biological activity: The Specific activity of TBK1-27920TH was determined to be 305 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: TBK1 TANK-binding kinase 1 [ Homo sapiens ]
• Official Symbol: TBK1
• Synonyms: TBK1; TANK-binding kinase 1; serine/threonine-protein kinase TBK1; NAK
• Gene ID: 29110
• mRNA Refseq: NM_013254
• Protein Refseq: NP_037386
• MIM: 604834
• Uniprot ID: Q9UHD2
• Chromosome Location: 12q14.2
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Hepatitis C, organism-specific biosystem
• Function: ATP binding; nucleic acid binding; nucleotide binding; phosphoprotein binding; protein binding