Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human PTPN1

Cat.No. : PTPN1-537H
Product Overview : Recombinant Human protein tyrosine phosphatase, non-receptor type 1 was expressed inE.coliand it was purified by conventional column chromatographic techniques. MW = 37.3 kDa (321 aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : PTPN1-537H
Description : The protein coding region of the catalytic domain of PTP-1B (amino acids 1-321) was cloned into an E. coli expression vector. The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues.
Source : Escherichia Coli.
Form : Liquid. In 25 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT 2 mM β-mercaptoethanol, 1 mM EDTA, 20%Glycerol.
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PF D HSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPNTCGHFWEMVW EQKS R G V VML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYT VRQLEL ENLTTQETREILHFHYTTWPDFGVPESPAS FLNFLFKVRE SGS LSPE HGPV VV H CSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVLLEMRKFRMGLIQTADQL RFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPP KR IL E PH N .
Specific Acitivity : 10,000units/mg of PTP1B.
Unit Definition : One unit will hydrolyze 1nanomole of p-nitrophenyl phosphatate per minute at pH 7.4 at 37°C using 10mM of substrate.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PTPN1 protein tyrosine phosphatase, non-receptor type 1 [ Homo sapiens ]
Synonyms : PTPN1; protein tyrosine phosphatase, non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 1; EC 3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1B; PTP1B; OTTHUMP00000031266; protein tyrosine phosphatase 1B; Protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental
Gene ID : 5770
mRNA Refseq : NM_002827
Protein Refseq : NP_002818
MIM : 176885
UniProt ID : P18031
Chromosome Location : 20q13.1-q13.2
Pathway : Adherens junction; Insulin signaling pathway; Hemostasis; Integrin cell surface interactions
Function : hydrolase activity; insulin receptor binding; protein binding; protein tyrosine phosphatase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the impact of altered PTPN1 activity on obesity and related metabolic disorders? 10/12/2022

Altered PTPN1 activity is associated with obesity, as it impacts pathways involved in energy balance and fat storage.

How do genetic variations in PTPN1 contribute to metabolic disease susceptibility? 05/03/2020

Genetic variations in PTPN1 can affect its activity and thereby influence metabolic processes and disease risk.

What role does PTPN1 play in the development of insulin resistance and type 2 diabetes? 04/14/2020

PTPN1 is implicated in insulin resistance, potentially contributing to the development of type 2 diabetes.

How does PTPN1 regulate insulin signaling and glucose metabolism? 12/21/2018

It negatively regulates insulin signaling by dephosphorylating insulin receptor substrates, affecting glucose uptake and metabolism.

How does PTPN1 interact with other signaling molecules in regulating metabolic pathways? 02/15/2018

PTPN1 interacts with various signaling proteins, playing a role in diverse metabolic pathways including lipid and glucose metabolism.

What is the primary function of PTPN1 in cellular signaling? 04/04/2017

PTPN1, also known as Protein Tyrosine Phosphatase Non-Receptor Type 1, is key in dephosphorylating proteins involved in signal transduction.

What potential therapeutic applications could arise from targeting PTPN1 in metabolic diseases? 04/03/2017

Targeting PTPN1 could offer therapeutic benefits in treating insulin resistance, type 2 diabetes, and obesity.

Customer Reviews (3)

Write a review
Reviews
04/06/2023

    Timely and precise. Essential for achieving research goals.

    08/30/2020

      Efficient service, valuable insights. Key to research success.

      03/26/2018

        Saves time and resources. Critical for our research.

        Ask a Question for All PTPN1 Products

        Required fields are marked with *

        My Review for All PTPN1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends