"DLL1" Related Products

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Recombinant Human Delta-like 1 (Drosophila), FLAG-tagged

Cat. No.: DLL1-2116H
Product Overview: Recombinant Human DLL1 was produced inHEK 293cells. Signal peptide and extracellular domain of recombinant human DLL1 (Delta-like protein 1; Delta1) (aa 1-545) are fused at the C-terminus to a FLAG-tag.
Description: DLL1 is the human homolog of the Drosophila Notch ligand Delta. Sequence analysis predicted that the 723-aa DLL1 transmembrane protein, which is 88% identical to the mouse DLL1 protein, has a DSL domain followed by 8 tandem EGF-like repeats and a short cytoplasmic C-terminal region. A soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal aa inhibited the differentiation of myeloid progenitors but promoted their expansion. DLL1 blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor. DLL1 undergoes proteolytic processing in its extracellular domain by ADAM10 and represents a substrate for several other members of the ADAM family. The soluble 38kDa Delta1 intracellular domain (DICD) that is generated by the presenilin-dependent γ-secretase cleavage is transported into the nucleus and likely plays a role in transcriptional events. Recently it has been shown that DLL1 is essential for postnatal arteriogenesis.
Source: HEK 293.
Purity: ≥90% (SDS-PAGE).
Formulation: Liquid. 0.2µm-filtered solution in PBS.
Endotoxin Content: <0.1EU/µg protein (LAL-test).
Biological Activity: Inhibits adipogenesis of mesenchymal stem cells.
Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
Gene Name: DLL1 delta-like 1 (Drosophila) [ Homo sapiens ]
Synonyms: DLL1; delta-like 1 (Drosophila); DL1; Delta; DELTA1; delta-like protein 1; H-Delta-1; delta-like 1 protein; drosophila Delta homolog 1; delta (Drosophila)-like 1; Delta1
Gene ID: 28514
mRNA Refseq: NM_005618
Protein Refseq: NP_005609
MIM: 606582
UniProt ID: O00548
Chromosome Location: 6q27
Pathway: Notch signaling pathway
Function: Notch binding; calcium ion binding; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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