Recombinant Human Delta-like 1 (Drosophila), FLAG-tagged
| Cat.No. : |
DLL1-2116H |
| Product Overview : |
Recombinant Human DLL1 was produced inHEK 293cells. Signal peptide and extracellular domain of recombinant human DLL1 (Delta-like protein 1; Delta1) (aa 1-545) are fused at the C-terminus to a FLAG-tag. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
DLL1-2116H |
| Description : |
DLL1 is the human homolog of the Drosophila Notch ligand Delta. Sequence analysis predicted that the 723-aa DLL1 transmembrane protein, which is 88% identical to the mouse DLL1 protein, has a DSL domain followed by 8 tandem EGF-like repeats and a short cytoplasmic C-terminal region. A soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal aa inhibited the differentiation of myeloid progenitors but promoted their expansion. DLL1 blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor. DLL1 undergoes proteolytic processing in its extracellular domain by ADAM10 and represents a substrate for several other members of the ADAM family. The soluble 38kDa Delta1 intracellular domain (DICD) that is generated by the presenilin-dependent γ-secretase cleavage is transported into the nucleus and likely plays a role in transcriptional events. Recently it has been shown that DLL1 is essential for postnatal arteriogenesis. |
| Source : |
HEK 293. |
| Purity : |
≥90% (SDS-PAGE). |
| Formulation : |
Liquid. 0.2µm-filtered solution in PBS. |
| Endotoxin Content : |
<0.1EU/µg protein (LAL-test). |
| Biological Activity : |
Inhibits adipogenesis of mesenchymal stem cells. |
| Stability : |
Working aliquots are stable for up to 3 months when stored at -20°C. |
| Gene Name : |
DLL1 delta-like 1 (Drosophila) [ Homo sapiens ] |
| Synonyms : |
DLL1; delta-like 1 (Drosophila); DL1; Delta; DELTA1; delta-like protein 1; H-Delta-1; delta-like 1 protein; drosophila Delta homolog 1; delta (Drosophila)-like 1; Delta1 |
| Gene ID : |
28514 |
| mRNA Refseq : |
NM_005618 |
| Protein Refseq : |
NP_005609 |
| MIM : |
606582 |
| UniProt ID : |
O00548 |
| Chromosome Location : |
6q27 |
| Pathway : |
Notch signaling pathway |
| Function : |
Notch binding; calcium ion binding; protein binding |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
