| Cat. No. : | NQO2-2055H |
| Product Overview : | Recombinant human NQO2 protein fused to His-tag was expressed inE.coliand purified by using conventional chromatography techniques. 28.1 kDa (251aa). |
| Description : | NQO2 is a member of the NAD(P)H dehydrogenase (quinone). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity. |
| Source : | E.coli. |
| Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT. |
| Purity : | > 95% by SDS - PAGE. |
| Concentration : | 1 mg/ml (determined by Bradford assay). |
| Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q. |
| Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| PDB rendering based on 1qr2. : |
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| Gene Name : | NQO2 NAD(P)H dehydrogenase, quinone 2 [ Homo sapiens ] |
| Synonyms : | NAD(P)H dehydrogenase, quinone 2; QR2; DHQV; DIA6; NMOR2; NQO2; ribosyldihydronicotinamide dehydrogenase; quinone reductase 2; NRH:quinone oxidoreductase 2; NRH dehydrogenase [quinone] 2; NAD(P)H menadione oxidoreductase 2, dioxin-inducible; NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2; OTTHUMP00000015953; OTTHUMP00000015949; Quinone reductase 2; EC 1.10.99.2 |
| Gene ID : | 4835 |
| mRNA Refseq : | NM_000904 |
| Protein Refseq : | NP_000895 |
| MIM : | 160998 |
| UniProt ID : | P16083 |
| Chromosome Location : | 6pter-q12 |
| Function : | NADPH dehydrogenase (quinone) activity; coenzyme binding; dihydronicotinamide riboside quinone reductase activity; electron carrier activity; metal ion binding |
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