Recombinant Human NAD(P)H Dehydrogenase, Quinone 2, His-tagged NQO2-2055H

Cat. No.:	NQO2-2055H
Product Overview:	Recombinant human NQO2 protein fused to His-tag was expressed inE.coliand purified by using conventional chromatography techniques. 28.1 kDa (251aa).
Description:	NQO2 is a member of the NAD(P)H dehydrogenase (quinone). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity.
Source:	E.coli.
Form:	Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
Purity:	> 95% by SDS - PAGE.
Concentration:	1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids:	MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q.
Storage:	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

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Gene Name:	NQO2 NAD(P)H dehydrogenase, quinone 2 [ Homo sapiens ]
Synonyms:	NAD(P)H dehydrogenase, quinone 2; QR2; DHQV; DIA6; NMOR2; NQO2; ribosyldihydronicotinamide dehydrogenase; quinone reductase 2; NRH:quinone oxidoreductase 2; NRH dehydrogenase [quinone] 2; NAD(P)H menadione oxidoreductase 2, dioxin-inducible; NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2; OTTHUMP00000015953; OTTHUMP00000015949; Quinone reductase 2; EC 1.10.99.2
Gene ID:	4835
mRNA Refseq:	NM_000904
Protein Refseq:	NP_000895
MIM:	160998
UniProt ID:	P16083
Chromosome Location:	6pter-q12
Function:	NADPH dehydrogenase (quinone) activity; coenzyme binding; dihydronicotinamide riboside quinone reductase activity; electron carrier activity; metal ion binding