"PDK4" Related Products


Recombinant Human PDK4, His-tagged

Cat. No. : PDK4-653H
Product Overview : Recombinant Human PDK4 with a His tag is expressed inBacteriaand column-purified.
Description : PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
Source : Bacteria.
Storage : Store at -80°C.
Gene Name : PDK4 pyruvate dehydrogenase kinase, isozyme 4 [ Homo sapiens ]
Synonyms : PDK4; pyruvate dehydrogenase kinase, isozyme 4; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; EC; FLJ40832
Gene ID : 5166
mRNA Refseq : NM_002612
Protein Refseq : NP_002603
MIM : 602527
UniProt ID : Q16654
Chromosome Location : 7q21.3
Pathway : Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
Function : ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity

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