"PDK4" Related Products

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Recombinant Human PDK4, His-tagged

Cat. No.: PDK4-653H
Product Overview: Recombinant Human PDK4 with a His tag is expressed inBacteriaand column-purified.
Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
Source: Bacteria.
Storage: Store at -80°C.
Gene Name: PDK4 pyruvate dehydrogenase kinase, isozyme 4 [ Homo sapiens ]
Synonyms: PDK4; pyruvate dehydrogenase kinase, isozyme 4; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; EC 2.7.11.2; FLJ40832
Gene ID: 5166
mRNA Refseq: NM_002612
Protein Refseq: NP_002603
MIM: 602527
UniProt ID: Q16654
Chromosome Location: 7q21.3
Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
Function: ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity

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