Cat. No. :	SGK1-755H
Product Overview :	Recombinant Human SGK1 (1-431 aa) is expressed in E.Coli with a T7 tag at N-terminus.
Description :	SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase. SGK1 mRNA is expressed in all tissues and the level of SGK1 mRNA is increased by stimulation with serum or dexamethasone. SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1. SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1.
Source :	E.Coli.
MW :	48942 Da.
Purity :	95%.
Formulation :	10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3. 10mM DTT.
Application :	MS. SDS.

Gene Name :	SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens ]
Synonyms :	SGK1; serum/glucocorticoid regulated kinase 1; SGK; serine/threonine protein kinase SGK; EC 2.7.11.1; serum/glucocorticoid regulated kinase; OTTHUMP00000017247; Serum/glucocorticoid-regulated kinase 1; Serum/glucocorticoid-regulated kinase 1
Gene ID :	6446
mRNA Refseq :	NM_001143676
Protein Refseq :	NP_001137148
MIM :	602958
UniProt ID :	O00141
Chromosome Location :	6q23
Function :	ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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