Recombinant Human RIPK2, GST-His
Cat.No. : | RIPK2-711H |
Product Overview : | Recombinant Human RIPK2, N-terminal fragment, amino acids M1-E299, N-terminal GST-HIS6 fusion protein with a Thrombin cleavage site, was expressed inSf9insect cells.MW = 63,815 Da. |
- Specification
- Gene Information
- Related Products
Cat. No. : | RIPK2-711H |
Description : | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli. |
Source : | Baculovirus infected Sf9 cells. |
Purification : | GST-Affinity Chromatography. |
Product Identity : | RIPK2 was confirmed as RIPK2 by mass spectroscopy LC-ESI-MS/MS. |
Storage Buffer : | 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol. |
Concentration : | 0.206 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein). |
Specific Activity : | 11 pmol/μg×min. |
Storage : | -80°C. Avoid repeated freeze-thaw cycles! |
Gene Name : | RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ] |
Synonyms : | RIPK2; receptor-interacting serine-threonine kinase 2; CARD-carrying kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; EC 2.7.11.1 |
Gene ID : | 8767 |
mRNA Refseq : | NM_003821 |
Protein Refseq : | NP_003812 |
MIM : | 603455 |
UniProt ID : | O43353 |
Chromosome Location : | 8q21 |
Pathway : | NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Signaling in Immune system; Signalling by NGF |
Function : | ATP binding; CARD domain binding; LIM domain binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; signal transducer activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
Ripk2-5522M | Recombinant Mouse Ripk2 Protein, Myc/DDK-tagged | +Inquiry |
RIPK2-5565H | Recombinant Human RIPK2, GST-tagged | +Inquiry |
RIPK2-7616M | Recombinant Mouse RIPK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
RIPK2-5564H | Recombinant Human RIPK2 Protein, His-tagged | +Inquiry |
RIPK2-9761Z | Recombinant Zebrafish RIPK2 | +Inquiry |
◆ Lysates | ||
RIPK2-2333HCL | Recombinant Human RIPK2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1623 | RIPK2 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionRIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.
RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.
Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.
RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.
RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.
RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.
Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.
Customer Reviews (3)
Write a reviewPrecise mass spectrometry analysis, key for our proteomics investigations.
Dependable protein purification, consistently delivers high yield and purity.
Great antibody validation, enhances our immunoprecipitation success.
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