"SGK2" Related Products

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Recombinant Human Serum/Glucocorticoid Regulated Kinase 2

Cat. No.: SGK2-659H
Description: SGK2 is a member of the serum- and glucocorticoid-induced kinases (SGK) which are serine-threonine kinases and belong to the "AGC" kinase subfamily, which includes protein kinases A, G, and C, and its catalytic domain is most similar to protein kinase B (PKB). SGK2, like the other two isoforms SGK1 and SGK3, is stimulated by insulin and insulin-like growth factor-1 (IGF-1), and has been shown to enhance Na(+)/K(+)-ATPase activity in a variety of cells.
Source: E.coli.
Application: Kinase activity is measured as the molar amount of phosphate incorporated into the Akt/SGK substrate peptide (RPRAATF), per minute per mg protein at 30 °C using a final concentration of 50 μM [32P] ATP.
Biochem/physiol Actions: SGK2 is a member of the serum- and glucocorticoid-induced kinases (SGK) which are serine-threonine kinases and belong to the "AGC" kinase subfamily, which includes protein kinases A, G, and C and has SGK2 enhances Na+/K+-ATPase activity in a variety of cells. In addition, SGK2 mimics the function of SGK1 and SGK3 and participates in the regulation of renal epithelial Na+ channel ENaC activity.
Physical Form: Supplied at 50 μL in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM dithiothreitol (DTT), 0.1 mM EGTA, and 30% glycerol.
Assay: ≥75% (SDS-PAGE).
Form: aqueous glycerol solution.
Mol Wt: protein apparent mol wt ~66 kDa.
Storage Temp: −70°C.
Gene Name: SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens ]
Synonyms: SGK2; serum/glucocorticoid regulated kinase 2; H-SGK2; dJ138B7.2; OTTHUMP00000031705; EC 2.7.11.1; OTTHUMP00000031702; OTTHUMP00000031703; Serum/glucocorticoid-regulated kinase 2; Serine/threonine-protein kinase Sgk2
Gene ID: 10110
mRNA Refseq: NM_016276
Protein Refseq: NP_057360
MIM: 607589
UniProt ID: Q9HBY8
Chromosome Location: 20q13.2
Function: ATP binding; nucleotide binding; potassium channel regulator activity; protein serine/threonine kinase activity; sodium channel regulator activity; transferase activity

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