Active GMP Recombinant Mouse Il6 protein

• Cat.No.: Il6-044MG
• Product Overview: GMP Recombinant Mouse Il6 protein(NP_112445.1)(193 aa), fused with His Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines.

Specification

• Source: HEK293
• Species: Mouse
• Form: Freeze-dried powder contains Sterile PBS (pH 7.4) with 6% mannitol.
• Bio-activity: Cell proliferation analysis uses T1165.85.2.1 mouse plasma cells to determine ED50, which is 0.1-0.6ng/mL.
• Molecular Mass: Recombinant Mouse IL-6contains 193 aa. It has a predicted MW of 22.6 kDa.
• Protein length: DNA sequence encoding Mouse IL-6(NP_112445.1) was expressed with His tag at the C-terminal.
• Endotoxin: <2EU/ug
• Purity: >=95% by SDS-PAGE and HPLC
• Storage: The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Il6 interleukin 6 [ Mus musculus ]
• Official Symbol: Il6
• Synonyms: Il; Il-6
• Gene ID: 16193
• mRNA Refseq: NM_031168
• Protein Refseq: NP_112445
• UniProt ID: P08505

Reviews

03/05/2022

Accurate localization and function within the cell.

01/31/2021

The binding affinity and affinity constant with the target are high.

03/12/2020

Can form a stable micellar structure.

Q&As

What is the dosage and usage of Il6?

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6?

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma?

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases?

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used?

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells?

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.