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Official Full Name interleukin 6
Background This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
Synonyms IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor;
    • Species :
    • Atlantic Salmon
    • Bovine
    • Canine
    • Cat
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Human
    • Macaca mulatta
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Zebrafish
    • Source :
    • Barley Grain
    • Cat
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Nicotiana Benthamiana
    • P.pastoris
    • Rabbit
    • Rat
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • APC
    • Biotin
    • Fc
    • His
    • GST
    • T7
    • HQ
    • Met
    • MYC/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL6-068H Recombinant Human IL6 Protein E. coli
    Human CAB11567RH Rabbit Anti-Human Interleukin 6 Monoclonal Antibody Rabbit N/A
    Human DMABT-H19252 Rat Anti-IL6 Monoclonal Antibody Rat APC
    Human DMABT-H19253 Rat Anti-IL6 Monoclonal Antibody Rat Biotin
    Human IL6-001H Recombinant Human IL6 Protein E.coli
    Human IL6-002H Recombinant Human IL6 Protein, His-tagged E.coli His
    Human IL6-040H Recombinant Human IL6 Protein, non-tagged, Biotinylated HEK293 N/A
    Human IL6-041H Recombinant Human IL6 Protein HEK293 N/A
    Human IL6-052H Recombinant Human IL6 Mutant (R44M) Protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IL6-100H Human Interleukin-6 (rDNA derived) Reference standard N/A
    Human IL6-1045H Recombinant Human IL6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL6-105H Recombinant Human IL6, His-tagged E.coli His
    Human IL6-106H Recombinant Human IL6 Nicotiana Benthamiana N/A
    Human IL6-128H Recombinant Human Interleukin 6 (Interferon, Beta 2) HEK293 N/A
    Human IL6-12H Recombinant Human IL6 protein E.coli N/A
    Human IL6-142H Recombinant Human IL6 Active, His-tagged Nicotiana Benthamiana His
    Human IL6-1558H Recombinant human IL6, Active, His-tagged Nicotiana Benthamiana His
    Human IL6-163H Recombinant Human Interleukin 6, HIgG1 Fc-tagged CHO Fc
    Human IL6-1H Recombinant Human IL6 Sf9 Insect Cell N/A
    Human IL6-210HG GMP Recombinant Human IL6 Protein E. coli
    Human IL6-213HG GMP Recombinant Human IL6 protein HEK293
    Human IL6-23H Recombinant Human IL6 CHO N/A
    Human IL6-264H Recombinant Human IL6, StrepII-tagged Human Cell Strep II
    Human IL6-28H Recombinant Human IL6, His-tagged Barley Grain His
    Human IL6-311H Recombinant Human IL6, MIgG2a Fc-tagged CHO Fc
    Human IL6-312H Recombinant Human IL6,HIgG1 Fc-tagged, mutant CHO Fc
    Human IL6-313H Recombinant Human IL6, HIgG1 Fc-tagged CHO Fc
    Human IL6-318H Recombinant Human IL6, Fc-tagged CHO Fc
    Human IL6-323H Recombinant Human IL6, His-tagged E.coli His
    Human IL6-363H Recombinant Human Interleukin 6 (interferon, beta 2) P.pastoris N/A
    Human IL6-4321HG GMP Recombinant Human IL6 protein E.coli N/A
    Human IL6-505H Recombinant Human IL6 protein HEK293
    Human IL6-5224HCL Recombinant Human IL6 293 Cell Lysate HEK293 N/A
    Human IL6-5309H Recombinant Human Interleukin 6 (interferon, beta 2), HQ-tagged Hordeum Vulgare HQ
    Human IL6-554H Recombinant Human IL6 protein, His-tagged HEK293F His
    Human IL6-62H Recombinant Human Interleukin 6 (interferon, beta 2) CHO N/A
    Human IL6-78H Recombinant Human IL-6 Yeast N/A
    Human IL6-8865H Recombinant Human IL6,His-tagged Hordeum Vulgare N/A
    Mouse DMABT-H18984 Rat Anti-IL6 Monoclonal Antibody Rat APC
    Mouse DMABT-H18985 Rat Anti-IL6 Monoclonal Antibody Rat Biotin
    Mouse IL6-001M Recombinant Mouse IL6, MIgG2a Fc-tagged CHO Fc
    Mouse Il6-044MG GMP Recombinant Mouse Il6 protein, His-tagged HEK293 His
    Mouse Il6-113M Recombinant Mouse Il6 Protein E.coli
    Mouse Il6-114M Recombinant Mouse Il6 Protein E.coli
    Mouse Il6-115M Recombinant Mouse Il6 Protein E.coli
    Mouse Il6-116M Recombinant Mouse Il6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il6-12M Recombinant Mouse Il6 protein E.coli N/A
    Mouse Il6-136M Mouse Interleukin-6 (rDNA derived) Reference standard N/A
    Mouse IL6-2003M Recombinant Mouse IL6 Protein E.coli N/A
    Mouse IL6-314H Recombinant Human IL6, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il6-320M Recombinant Mouse Il6, Fc-tagged HEK293 Fc
    Mouse Il6-321M Recombinant Mouse Il6, Fc-tagged CHO Fc
    Mouse Il6-37M Recombinant Mouse Il6 protein, His-tagged Insect Cell His
    Mouse Il6-490M Recombinant Mouse Il6 protein, His-tagged HEK293F His
    Mouse IL6-605M Recombinant Mouse interleukin 6 (interferon, beta 2), His-tagged E.coli His
    Mouse Il6-657M Recombinant Mouse Interleukin 6 E.coli N/A
    Mouse Il6-7246M Recombinant Mouse Il6 Protein, His-tagged E.coli His
    Mouse Il6-76M Recombinant Mouse Interleukin 6 E.coli N/A
    Mouse Il6-8668M Recombinant Mouse Il6, None tagged E.coli N/A
    Rat IL6-3049R Recombinant Rat IL6 Protein Mammalian Cell His
    Rat Il6-473R Recombinant Rat Il6 protein E.coli N/A
    Rat Il6-481R Recombinant Rat Il6 protein, His-tagged HEK293F His
    Rat IL6-8710R Recombinant Rat Il6 E.coli N/A
    Rat Il6-98R Recombinant Rat Interleukin 6 E.coli N/A
    Cynomolgus Monkey IL6-326 Recombinant Cynomolgus Monkey IL6 protein Yeast N/A
    Cynomolgus Monkey IL6-8849C Recombinant Cynomolgus IL6, None tagged E.coli His
    Rhesus Macaque IL6-2254R Recombinant Rhesus monkey IL6 Protein, His-tagged Mammalian Cell His
    Rhesus IL6-560R Recombinant Rhesus IL6 protein E.coli N/A
    Rhesus monkey IL6-659R Recombinant Rhesus monkey IL6 protein, His-tagged E.coli His
    Canine IL6-144C Recombinant Canine IL6 protein, His-tagged Insect Cell His
    Canine IL6-244C Recombinant Canine Interleukin 6 (Interferon, Beta 2) Yeast N/A
    Dog IL6-498D Recombinant Dog IL6 protein, His-tagged HEK293F His
    Dog IL6-654D Recombinant Dog IL6 protein, His & T7-tagged E.coli His/T7
    Bovine IL6-241B Recombinant Bovine Interleukin 6 (Interferon, Beta 2) Yeast N/A
    Chicken IL6-12C Recombinant Chicken IL6 Protein Yeast N/A
    Rabbit IL6-4372R Recombinant Rabbit IL6 Protein Yeast N/A
    Chicken IL6-597C Recombinant Chicken Interleukin 6 (interferon, beta 2), His-tagged E.coli His
    Chicken IL6-6196C Recombinant Chicken IL6 Mammalian Cell His
    Rabbit IL6-658R Recombinant Rabbit IL6 protein, His & GST-tagged E.coli His/GST
    Zebrafish il6-23Z Recombinant Zebrafish il6 Protein Yeast N/A
    Zebrafish IL6-8236Z Recombinant Zebrafish IL6 Mammalian Cell His
    Pig IL6-1025P Recombinant Pig IL6 Protein E.coli N/A
    Pig Il6-16S Recombinant Swine Il6 Yeast N/A
    Equine IL6-258E Recombinant Equine Interleukin 6 (Interferon, Beta 2) Yeast N/A
    Pig IL6-29S Recombinant Swine IL-6 Yeast N/A
    Cotton Rat Il6-392C Recombinant Cotton Rat Il6, Met-tagged E.coli Met
    Atlantic Salmon IL6-4394A Recombinant Atlantic Salmon IL6 Protein Yeast N/A
    Pig IL6-474P Recombinant Pig IL6 protein, His-tagged HEK293F His
    Macaca mulatta IL6-5433M Recombinant Macaca mulatta Interleukin 6 (interferon, beta 2) E.coli N/A
    Cat IL6-598C Recombinant Cat Interleukin 6 (interferon, beta 2) Cat N/A
    Sheep IL6-655S Recombinant Sheep IL6 protein, His-tagged E.coli His
    Pig IL6-85P Recombinant Porcine Interleukin 6 E.coli N/A

    Il6 involved in several pathways and played different roles in them. We selected most pathways Il6 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL20; Il2; IL3; PDGFRB; IL7; IL10RA; CCL4L1; Fasl; Ccl21c; GM10591
    HIF- signaling pathway TEK; ANGPT4; PFKFB3; AKT2; MKNK2; NPPA; RPS6; EP300; PIK3CA; MTOR
    FoxO signaling pathway AKT2; TGFB2; AGAP2; G6PCA.1; RAF1A; BRAF; KLF2A; HRASB; RAG2; S1PR4
    PIK-Akt signaling pathway IFNA14; LAMA1; PKN3; PPP2R5C; YWHAZ; Ifna15; IKBKG; G6PC2; FLT1; IFNA16
    Toll-like receptor signaling pathway IKBKG; TLR3; FADD; MAP2K4A; IL6; CXCL9; PIK3CB; IRF3; IFNA17; IFNA1
    NOD-like receptor signaling pathway MAPK12B; TNFAIP3; NFKBIB; HSP90AA1.1; CARD8; MAPK11; MAPK8; NAIP7; PYCARD; CASP1
    Cytosolic DNA-sensing pathway POLR2E; CCL4L1; IFNB1; IFNA2; POLR3GLB; NFKB1; LOC100033925; IFNA5; IKBKG; POLR3A
    Jak-STAT signaling pathway IL6ST; STAT6; SOCS5; LEP; AOX2P; MCL1A; MCL1; PIK3R5; BCL2A; GRB2A
    Hematopoietic cell lineage CD1D2; CD1E, B2M; FCGR1A; GYPA; IL4R; ITGA2B; CD5; TNF; GP9; CD1E
    TNF signaling pathway TNF; CCL5; IL1B; MAP3K7; CXCL1; TNFRSF1A; IKBKG; IL15; BIRC2; CXCL10
    Intestinal i TNFRSF13B; H2-AA; CD40; MHC2A; CCL25B; HLA-DMA; IL15; Icosl; AICDA; TGFB1
    ne network for IgA production BMA1; CXCL12A; IL-15RA; HLA-DRB5; IL5; HLA-DPB1; HLA-DOB; MHC2DEB; HLA-DQB1; CXCR4
    Insulin resistance PPP2R4; PTPN11A; MAPK9; PTPRFB; ACACB; MGEA5; PTPRF; MAPK8; PPP1CBL; SREBF1
    Non-alcoholic fatty liver disease (NAFLD) PPARA; TNF; UQCRQ; BAX; IKBKB; COX6A2; NDUFA7; PRKAG2; NDUFS3; INS1
    Prion diseases C7; NCAM1; C9; LAMC1; BAX; PRNP; HSPA5; PRKACB; HSPA1A; FYN
    Salmonella infection CDC42L; TLR5; DYNC1LI1; RHOGC; MYH10; ACTB2; RAC1A; MAPK8; RAC1; MYD88
    Pertussis MYD88; CALM4; ITGB1; CASP7; FOS; ITGB2; NLRP3; MAPK13; MAPK8; MAPK10
    Legionellosis IL-8; EEF1A2; CASP8; APAF1; NFKB1; NLRC4; HSPA2; SEC22B; IL1B; TLR2
    Chagas disease (American trypanosomiasis) PPP2R2B; TRAF6; IL-8; NFKBIA; CCL5; IKBKG; PIK3R2; CCL3L3; TGFB3; PPP2CB
    African trypanosomiasis IDO2; HBA-A2; HPR; PLCB1; IL12B; LAMA4; FASLG; MYD88; HBA2; Fasl
    Tuberculosis CAMK2A; CEBPG; CALM3; IFNA12; STAT1; IFNA16; Il23a; Il12b; MAPK8; FCGR2C; TRAF6
    Measles CD209B; Fasl; OAS1A; IFIH1; IFNG; IFNAR2; CD3D; CD209; MYD88; TP73
    HTLV-I infection HLA-DQB1; VDAC1; BAX; WNT11; FZD5; ATF3; PPP3CA; AKT2; POLE; VDAC2
    Herpes simplex infection MCRS1; HLA-DMB; C3A.3; HLA-C; MAVS; IFNG; MHC2DEB; STAT1A; NXF2; PPP1CC
    Pathways in cancer PDGFB; KIT; COL4A1; TGFB2; FH1; FZD9; WNT9A; ROCK1; BIRC5; TGFB1
    Transcriptional misregulation in cancer SS18; MPO; ETV4; FLT1; IL2RB; CCND2; NR4A3; TMPRSS2; MEIS1; NFKBIZ
    Inflammatory bowel disease (IBD) HLA-DPB1; IFNGR1; IL18; TLR4; HLA-DQB1; RELA; IL13; IL22; IL18R1; IL4R
    Rheumatoid arthritis TLR2; CD86; HLA-DRB1; HLA-DRB5; VEGFA; MMP1; ATP6V1G1; CCL20; CXCL6; ATP6V0E
    Graft-versus-host disease IL1A; KIR3DL1; HLA-DQB1; HLA-DOA; KIR2DL1; KIR3DL2; HLA-A; PRF1; Il2; HLA-DQA1
    Hypertrophic cardiomyopathy (HCM) ITGB8; SGCB; ITGA10; ITGA8; TGFB3; CACNA2D3; MYBPC3; EMD; SLC8A1; TGFB2

    Il6 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6 itself. We selected most functions Il6 had, and list some proteins which have the same functions with Il6. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity AIMP1; LTB; IL37; SECTM1; RNF207B; GDF6B; LFT1; ADIPOQ; IL1A; IL4
    growth factor activity HDGFRP3; FGF18B; LIF; FGF10A; PPBP; GDF15; CSF2; GPI; LEP; BMP3
    interleukin-6 receptor binding PYCARD; ERAP1; CNTF; ADAM17; IL6
    contributes_to interleukin-6 receptor binding IL6R; IL6ST; Il6ra; IL6
    protein binding CCPG1; RAB43; C1D; SUGT1; POLG2; GRIN3A; TSTD2; VCAN; REV1; MAPRE1

    Il6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6.

    IL6R; ZBTB16; HRH1; IL6ST; SH3GL2


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