Il6
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Official Full Name
interleukin 6
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Background
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] -
Synonyms
IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il6 Related Gene Family
- Il6 Related Research Area
- Il6 Related Signal Pathway
Il6 involved in several pathways and played different roles in them. We selected most pathways Il6 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL11;CXCL10;IFNGR2;IL6R;IFNA2;IFNA6;CCL15;CXCL12A;KITLGA |
| HIF- signaling pathway | PRKCG;ERBB2;Il6ra;IL6R;PRKCA;PLCG2;RELA;ANGPT1;ANGPT4 |
| FoxO signaling pathway | GRB2;MAPK12;BCL6A;SMAD2;STK4;RAG1;CCND2;MAPK10;FASLG |
| PIK-Akt signaling pathway | YWHAB;ATF4;FGFR4;ITGA3;PIK3R5;FGF3;EIF4E1B;FGF10;TCL1B1 |
| Toll-like receptor signaling pathway | IKBKE;SPP1;MAPK14A;PIK3CD;IFNA16;Ifna11;RAC1;TMED7-TICAM2;CRFB2 |
| NOD-like receptor signaling pathway | NLRC4;MAPK12;RIPK2;LOC100033925;ERBB2IP;NFKBIA;MAPK1;SUGT1;MAPK8B |
| Cytosolic DNA-sensing pathway | IFNA14;CXCL10;IKBKE;NFKBIB;TREX1;IFNA5;IL33;NFKBIAA;CCL5 |
| Jak-STAT signaling pathway | GM2002;IFNK;STAT2;SOCS9;IL2RGB;CSH2;IL23;CSH1;TP-1 |
| Hematopoietic cell lineage | CD1d1;Flt3l;IL2RA;CD3E;CD8B1;CD44;CD3G;HLA-DRB3;DNTT |
| TNF signaling pathway | SOCS3;CXCL10;MAP2K3;MAGI2;CCL2;IL15;PIK3R1;TRAF1;TRAF3 |
| Intestinal i | TNFSF13;AICDA;ITGA4;TNFRSF13B;HLA-DQA1;IL6;CXCR4A;BMA1;MHC2DCB |
| ne network for IgA production | CXCR4A;TGFB1;CCL25;HLA-DOA;CXCL12;HLA-DQA1;CCL28;TNFRSF17;AICDA |
| Insulin resistance | SREBF1;PIK3R2;RPS6KA3;PPP1R3DA;PIK3CG;NFKBIAB;AKT1;PTPRFB;PRKCBB |
| Non-alcoholic fatty liver disease (NAFLD) | COX6B2;XBP1;TRAF2;NDUFA10;PRKAG2;COX7A1;LEPR;FASLG;NDUFC2 |
| Prion diseases | C9;MAPK3;C1QA;PRKACB;HSPA5;LAMC1;NCAM1;SOD1;PRKACG |
| Salmonella infection | PKN1;DYNC1LI1;RAB7;MAPK11;CCL4L2;MAPK14B;MYH10;ROCK1;MAPK3 |
| Pertussis | TNF;C1RA;CASP7;CALM1;Itgam&Itgb2;NLRP3;MAPK1;ITGB1;C4A |
| Legionellosis | TLR2;CASP1;ITGB2L;TLR4;TLR5;RAB1B;NAIP7;EEF1A2;IL1B |
| Chagas disease (American trypanosomiasis) | GNAS;CALR;CXCL8;SMAD2;FOS;PIK3R1;TGFBR1;GNAL;GNAI2 |
| African trypanosomiasis | HBA2;FAS;VCAM1;APOL1;IL12B;MYD88;ICAM1;IDO2;PLCB3 |
| Malaria | HBA-A2;GYPB;GYPA;COMP;TGFB3;CD81;KLRK1;CCL2;CD40 |
| Amoebiasis | C9;COL1A2;NFKB1;TLR2;ADCY1;COL4A3;HSPB1;SERPINB13;GNA15 |
| Tuberculosis | TLR2;FCER1G;IL18;CAMK2D;IFNA6;FCGR2B;IL10RA;ARHGEF12;NFKB1 |
| Hepatitis B | TGFB3;CCNA1;PIK3R3;TICAM2;IKBKG;GRB2;PIK3CD;IFNA5;BAX |
| Measles | IFNA4;TBK1;PIK3CD;IL1A;TRP53;DDX58;CD3G;IFNA6;IL6 |
| Influenza A | OAS1;AKT1;NUP98;ICAM1;IL1B;VDAC1;MAPK3;IFNA2;PIK3CA |
| HTLV-I infection | CRTC3;CRTC2;NFKB1;ATF1;PIK3R3;PIK3R1;ZFP36;TBPL1;EGR1 |
| Herpes simplex infection | SRSF6;HLA-DRB1;MHC2DCB;CSNK2A2;HNRPKL;PTPN11B;TTC6;RNASEL;MAPK8 |
| Pathways in cancer | FZD1;GNG8;PTK2;BIRC8;FH;ITGA2B;LEF1;PLCB4;CSF1R |
| Transcriptional misregulation in cancer | PPARG;CEBPE;FEV;NUPR1;TFE3;MEIS1;ETV4;RXRA;TAF15 |
| Inflammatory bowel disease (IBD) | STAT4;STAT1;RORA;IL21;IL18;IL22;Il4ra;IL23;IL12A |
| Rheumatoid arthritis | HLA-DMA;TLR4;ATP6V1H;CCL3L1;IL23;ITGB2L;TGFB3;CXCL12;HLA-DRB4 |
| Graft-versus-host disease | HLA-DQA2;IFNG;Il2;HLA-C;FASLG;Fasl;H2-AB1;CD28;IL6 |
| Hypertrophic cardiomyopathy (HCM) | TGFB2;ATP2A2;TPM1;CACNG6;ITGB4;ITGA5;LMNA;PRKAG3;IGF1 |
Il6 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6 itself. We selected most functions Il6 had, and list some proteins which have the same functions with Il6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GREM2;AREG;IL17A;IL37;CCL20B;SP100;FGF2;IFNA10;LFT1 |
| growth factor activity | EGF;BMP2B;JAG1;GRN;PRL2C3;VEGFAA;RABEP2;PPBP;LEFTY2 |
| interleukin-6 receptor binding | CNTF;ERAP1;ADAM17;IL6;PYCARD |
| contributes_to interleukin-6 receptor binding | IL6ST;Il6ra;IL6;IL6R |
| protein binding | AGR2;COPS7B;VCPKMT;CLDN8;MOBKL1A;SELP;APOH;EBF2;BMPR1AA |
Il6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6.
IL6R; ZBTB16; HRH1; IL6ST; SH3GL2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
Customer Reviews (3)
Write a reviewCyclopeptide - Structural energy analysis technique that combines linear and circular peptide expression to predict and evaluate protein stability and structure. -
The secondary structure of IL6, such as α-helix, β-folding, etc. is evaluated, and the folding state and stability of the protein are detected. -
Molecular sieve grading techniques were used to assess the purity and presence of IL6 polymers by analyzing its molecular size and morphological distribution. -
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