il6
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  • Official Full Name
  • interleukin 6
  • Background
  • This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
  • Synonyms
  • IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor;
Cat.#:IL6-040HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6 Protein, non-tagged, Biotinylated
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Cat.#:IL6-2003MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IL6 Protein
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Cat.#:IL6-4372RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit IL6 Protein
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Cat.#:IL6-4394ATag:
Source (Host):YeastSpecies:Atlantic Salmon
Product nameRecombinant Atlantic Salmon IL6 Protein
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Cat.#:IL6-5433MTag:N/A
Source (Host):E. coliSpecies:Macaca mulatta
Product nameRecombinant Macaca mulatta Interleukin 6 (interferon, beta 2)
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Cat.#:IL6-471HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 (Interferon, Beta 2)
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Cat.#:IL6-363HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Interleukin 6 (interferon, beta 2)
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Cat.#:IL6-041HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IL6 Protein
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Cat.#:IL6-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6, His-tagged
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Cat.#:IL6-106HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human IL6
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Cat.#:IL6-128HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 6 (Interferon, Beta 2)
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Cat.#:IL6-12HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-6
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Cat.#:IL6-142HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human IL6 Active, His-tagged
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Cat.#:IL6-1558HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human IL6, Active, His-tagged
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Cat.#:IL6-163HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 6, HIgG1 Fc-tagged
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Cat.#:IL6-1HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IL6
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Cat.#:IL6-218HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6 Protein
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Cat.#:IL6-23HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6
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Cat.#:IL6-264HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6, StrepII-tagged
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Cat.#:IL6-2778HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6
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Cat.#:IL6-28HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human IL6, His-tagged
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Cat.#:IL6-304HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 (interferon, beta 2), Met
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Cat.#:IL6-311HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6, MIgG2a Fc-tagged
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Cat.#:IL6-312HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6,HIgG1 Fc-tagged, mutant
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Cat.#:IL6-313HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6, HIgG1 Fc-tagged
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Cat.#:IL6-318HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6, Fc-tagged
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Cat.#:IL6-505HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL-6
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Cat.#:IL6-554HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL6 protein, His-tagged
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Cat.#:IL6-62HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 6 (interferon, beta 2)
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Cat.#:IL6-63HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6, His-tagged
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Cat.#:IL6-78HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-6
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Cat.#:IL6-8865HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human IL6,His-tagged
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Cat.#:IL6-950HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6 Protein, His-tagged
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Cat.#:IL6-001MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL6, MIgG2a Fc-tagged
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Cat.#:Il6-12MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il6 protein
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Cat.#:IL6-314HTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Human IL6, MIgG2a Fc-tagged, mutant
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Cat.#:Il6-320MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il6, Fc-tagged
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Cat.#:Il6-321MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il6, Fc-tagged
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Cat.#:Il6-37MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Il6 protein, His-tagged
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Cat.#:Il6-490MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il6 protein, His-tagged
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Cat.#:IL6-605MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse interleukin 6 (interferon, beta 2), His-tagged
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Cat.#:Il6-76MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 6
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Cat.#:Il6-8668MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il6, None tagged
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Cat.#:IL6-3049RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL6 Protein
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Cat.#:Il6-473RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 6
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Cat.#:Il6-481RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Il6 protein, His-tagged
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Cat.#:IL6-8710RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il6
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Cat.#:Il6-98RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 6
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Cat.#:IL6-326Tag:
Source (Host):YeastSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey IL6 protein
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Cat.#:IL6-8849CTag:His
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL6, None tagged
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Cat.#:IL6-2254RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL6 Protein, His-tagged
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Cat.#:IL6-659RTag:His
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey IL6 protein, His-tagged
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Cat.#:IL6-144CTag:His
Source (Host):Insect cellsSpecies:Canine
Product nameRecombinant Canine IL6 protein, His-tagged
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Cat.#:IL6-244CTag:N/A
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine Interleukin 6 (Interferon, Beta 2)
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Cat.#:IL6-498DTag:His
Source (Host):HEK293FSpecies:Dog
Product nameRecombinant Dog IL6 protein, His-tagged
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Cat.#:IL6-654DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL6 protein, His & T7-tagged
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Cat.#:IL6-241BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 6 (Interferon, Beta 2)
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Cat.#:IL6-12CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken IL6 Protein
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Cat.#:IL6-6196CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL6
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Cat.#:IL6-658RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL6 protein, His & GST-tagged
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Cat.#:il6-23ZTag:
Source (Host):YeastSpecies:Zebrafish
Product nameRecombinant Zebrafish il6 Protein
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Cat.#:IL6-8236ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL6
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Cat.#:IL6-1025PTag:
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL6 Protein
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Cat.#:Il6-16STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine Il6
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Cat.#:IL6-258ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 6 (Interferon, Beta 2)
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Cat.#:IL6-29STag:
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine IL-6
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Cat.#:Il6-392CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il6, Met-tagged
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Cat.#:IL6-474PTag:His
Source (Host):HEK293FSpecies:Pig
Product nameRecombinant Pig IL6 protein, His-tagged
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Cat.#:IL6-655STag:His
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep IL6 protein, His-tagged
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Cat.#:IL6-85PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Interleukin 6
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Cat.#:IL6-5309HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Interleukin 6 (interferon, beta 2), HQ-tagged
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Cat.#:IL6-031ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6 (29-212aa)
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Cat.#:IL6-323HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6, His-tagged
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Cat.#:IL6-738HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 (interferon, beta 2), His-tagged
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Cat.#:Il6-657MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 6
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Cat.#:IL6-560RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus macaque IL-6
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Cat.#:IL6-597CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Interleukin 6 (interferon, beta 2), His-tagged
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Cat.#:IL6-598CTag:N/A
Source (Host):YeastSpecies:Cat
Product nameRecombinant Cat Interleukin 6 (interferon, beta 2)
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Cat.#:IL6-1112HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6
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Cat.#:IL6-5224HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL6 293 Cell Lysate
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Cat.#:IL6-4321HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL6 protein
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Cat.#:IL6-100HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-6 (rDNA derived) Reference standard
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Cat.#:Il6-136MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-6 (rDNA derived) Reference standard
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Involved Pathway

Il6 involved in several pathways and played different roles in them. We selected most pathways Il6 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNPHI3; CXCL16; PF4V1; CCR9A; TNFRSF11A; CCL4L2; CXCL2; CCR5; TNFRSF25; FIGF
HIF- signaling pathway
CAMK2B; ENO3; PIK3R2; PDHA1; EGLN1; NOS2; IL6R; MTOR; TEK; RPS6KB1
FoxO signaling pathway
PIK3R3A; PRKAB2; FOXO1A; INS2; GRB2; MAP2K2B; MAPK12B; S1PR4; SMAD4; GRM1
PIK-Akt signaling pathway
HGF; EPO; LPAR5; PPP2R1B; IL6; PRKCA; IFNA16; TNXB; THBS3; IFNA10
Toll-like receptor signaling pathway
STAT1A; IFNA12; PIK3R3; MAP2K2A; TLR7; MAPK13; CD14; CCL4L2; IFNA21; PIK3R3A
NOD-like receptor signaling pathway
ERBB2IP; IL8L1; PYDC1; IKBKB; MAPK13; CXCL8B.3; CARD18; IKBKG; NAIP1; MAPK10
Cytosolic DNA-sensing pathway
POLR3D; CXCL10; RIPK1L; OSTN; NFKB1; IFNA1; IFNA21; NFKBIB; IRF3; CCL4
Jak-STAT signaling pathway
GH2; EP300; IL6ST; SOCS4; IRX1; PRLR; SOCS3B; STAT5B; OSM; HRASB
Hematopoietic cell lineage
FCER2; GP5; Flt3l; CSF1R; CD33; CR1; CD9; GP1BA; CSF1; Il4ra
TNF signaling pathway
LTA; PGAM5; RPS6KA5; TNFRSF1B; PIK3CB; MAP2K3; TNF; TRAF2; TRADD; IL6
Intestinal i
ITGA4; MAP3K14; CD86; BMA1; IL5; HLA-DOB; HLA-DRB3; ICOSLG; ICOS; BLB1
ne network for IgA production
HLA-DPA1; HLA-DQA2; MHC2A; PIGR; ITGB7; ITGA4; CCL25B; HLA-DMB; ICOS; CD40
Insulin resistance
SOCS3B; PRKAG2A; PTPRFB; PRKCE; PPP1R3CA; PPP1CC; RPS6KA1; MAPK8A; IRS1; SLC2A1A
Non-alcoholic fatty liver disease (NAFLD)
PRKAG3; MAPK9; XBP1; PIK3CB; NDUFAB1; INS2; IRS1; NDUFB4; NDUFA10; AKT2
Prion diseases
C6; C9; IL1A; C1QA; HSPA5; NOTCH1; C1QB; C8A; NCAM1; FYN
Salmonella infection
ACTG1; ROCK2A; PKN2; MAPK9; CCL3L1; ARPC5A; RILP; WAS; MAPK14A; ROCK1
Pertussis
TICAM2; GNAI1; FOS; C1RA; ITGB1; RHOA; C4BPB; CFL2; SERPING1; CALM3
Legionellosis
HBS1L; SAR1B; NFKBIA; IL18; IL-8; ITGB2L; CR1; NFKB1; PYCARD; CASP7
Chagas disease (American trypanosomiasis)
PIK3CG; RELA; PIK3CD; TGFBR1; PIK3R1; PPP2R1A; BDKRB2; IFNB1; PLCB1; IFNG
African trypanosomiasis
IL12B; PLCB4; HPR; IDO1; IL10; HBA1; ICAM1; FAS; Fasl; HBA-A2
Malaria
IFNG; PECAM1; MYD88; THBS4; THBS1; SDC2; HGF; HBB-B2; TGFB3; ITGB2
Amoebiasis
C9; NFKB1; PLCB4; PLCB3; IL1R2; LAMB4; NOS2; ACTN2; PIK3CB; ADCY1
Tuberculosis
LBP; Casp3; BAX; NFYB; NFKB1; IL10RB; CYCS; IFNA6; MRC2; HLA-DPA1
Hepatitis B
IFNA7; CCNA1; TLR2; CCNE2; IFIH1; BIRC5; CCND1; TIRAP; IRF7; APAF1
Measles
RCHY1; EIF2AK2; TP73; PIK3CG; HSPA1B; IFNA16; IL4; HSPA2; IFNA12; TNFRSF10A
Influenza A
PLG; TLR7; IL1A; PIK3CD; OAS3; HLA-DRB5; DNAJC3; IFNA17; TNFRSF10B; NLRX1
HTLV-I infection
FOSL1; RELB; H2-AA; CRTC3; TGFB1; TERT; SMAD4; POLE4; Adcy4; FZD3
Herpes simplex infection
SFRS9; UBE2R2; HLA-DRB4; CUL1A; STAT1A; SKP2; TRAF2; MHC2DAB; Ifna15; MAVS
Pathways in cancer
GSTP1; PTGS2; HSP90AB1; DAPK3; TGFBR2; LAMA5; RALBP1; BAD; KIT; CDH1
Transcriptional misregulation in cancer
BCL2L1; HIST1H3A; TRP53; ASPSCR1; Itgam&Itgb2; PAX8; GZMB; IGF1R; JMJD1C; PLAT
Inflammatory bowel disease (IBD)
IFNGR2; HLA-DOA; RELA; TGFB1; IL12A; HLA-DRB4; STAT3; IL17A; MAF; STAT1
Rheumatoid arthritis
IFNG; HLA-DRB1; HLA-DRB3; ITGB2; CXCL12; HLA-DOB; IL1A; ATP6V1D; ATP6V0D1; CCL3
Graft-versus-host disease
HLA-DMB; HLA-C; FAS; HLA-DMA; KLRD1; CD80; HLA-A; HLA-DPA1; IL1B; KIR2DL1
Hypertrophic cardiomyopathy (HCM)
TGFB3; ITGA5; CACNA2D1; ITGA7; CACNB1; ITGB1; ITGAV; PRKAB1; ITGB8; PRKAG2

Protein Function

Il6 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6 itself. We selected most functions Il6 had, and list some proteins which have the same functions with Il6. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GPR19; IFNL3; GDF1; FASLG; LTA; BMP15; FAM3D; INHBE; IL7; IFNB
Function growth factor activity
Related Protein FGF1; FBRS; BTC; CLEC11A; GDF6; PRL2C2; NRG2; TGFB1; MDKA; GDF15
Function interleukin-6 receptor binding
Related Protein PYCARD; CNTF; ERAP1; ADAM17; IL6
Function contributes_to interleukin-6 receptor binding
Related Protein IL6ST; Il6ra; IL6R; IL6
Function protein binding
Related Protein FLAD1; TDP1; PARK7; SAP18; ZNF490; STOX1; RAP1A; ZSCAN12; INMT; KRTAP9-4

Interacting Protein

Il6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6.
IL6R; ZBTB16; HRH1; IL6ST; SH3GL2

Il6 Related Gene Family

IL