This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
Il6 involved in several pathways and played different roles in them. We selected most pathways Il6 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Il6 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6 itself. We selected most functions Il6 had, and list some proteins which have the same functions with Il6. You can find most of the proteins on our site.
Il6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6.
The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
What are the pharmacokinetic properties of Il6?
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Does Il6 have advantages in the treatment of multiple myeloma?
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Does Il6 have specific therapeutic effects for certain diseases?
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
In which diseases is Il6 widely used?
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
What is the effect of Il6 on immune cells?
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.